Inflammatory Lung Disease in Rett Syndrome

Table 3

Redox/antioxidant status in patients with typical Rett syndrome: systemic oxidative stress with decreased GSH/GSSG ratio.

Redox and antioxidant markers	Rett syndrome (𝑛=228)	Healthy controls (𝑛=114)	𝑃 value
P-NPBI (nmol/mL)	0.90±0.18	0.43±0.25	<0.0001
IE-NPBI (nmol/mL)	1.20±0.30	0.78±0.17	<0.0001
F2-IsoPs (pg/mL)	70.1±20.5	24.2±11.5	<0.0001
GSH (μmol/L)	1673.0±591.0	1165.0±132.0	<0.0001
GSSG (μmol/L)	179.0±73.9	3.55±1.90	<0.0001
GSH to GSSG ratio	10.9±5.5	160.0±61.0	<0.0001

P-NPBI: plasma non-protein-bound iron; IE-NPBI: intraerythrocyte non-protein-bound iron; F₂-IsoPs: plasma F₂-isoprostanes; GSH: reduced glutathione; GSSG: oxidized glutathione.