Inflammatory Lung Disease in Rett Syndrome

Table 4

Results of cardiorespiratory monitoring in patients with typical Rett syndrome (𝑛=228) confirming a high frequency of apneas and hypopneas either during wakefulness or sleep states.

Recorded events	Median events/h	Interquartile range
Sleep
Obstructive apneas	6.2	3.4–58
Central apneas	0.4	0.15–0.92
Mixed apneas	1.5	0.4–2.5
Hypopneas	25.6	20.1–34.7
Wakefulness
Obstructive apneas	17.7	4.9–11.38
Central apneas	0.7	0.08–1.07
Mixed apneas	1.7	0.92–2.4
Hypopneas	22	12.7–26

Apnoeas were defined as a >90% airflow decrease for ≥10 sec; hypopnoeas were defined as a >50% airflow reduction for ≥10 sec associated with a decrease of ≥3% in oxygen saturation [51]. Obstructive apneas refer to recorded events with cessation of airflow for ≥10 sec associated with persistent respiratory effort; central apneas refer to events characterized by cessation of airflow for ≥10 sec without associated respiratory effort; mixed apneas refer to respiratory events that begin as central apneas and end up as obstructive apneas.