Inflammatory Lung Disease in Rett Syndrome

Table 5

Correlation matrix between redox/antioxidant status and severity of recorded apnoeas, either during wakefulness or sleep, in patients with typical Rett syndrome (𝑁=228).

Redox and antioxidant markers	Apnoeas
	Mild	Moderate	Severe
P-NPBI	0.185; (0.1431)	0.176; (0.1631)	0.265; (0.0346)
IE-NPBI	0.324; (0.0089)	0.373; (0.0024)	0.358; (0.0037)
F2-IsoPs	0.2220; (0.0800)	0.225; (0.0744)	0.305; (0.0142)
GSH	0.252; (0.0449)	0.101; (0.4262)	0.183; (0.1485)
GSSG	0.258; (0.0392)	0.260; (0.0378)	0.267; (0.033)
GSH/GSSG ratio	−0.210; (0.0961)	−0.247; (0.0488)	−0.241; (0.0552)

Data are expressed as rank correlation rho coefficients with 𝑃 values in brackets. Bold characters indicate statistically significant associations. Apnoeas were defined as a >90% airflow decrease for ∼10 sec; hypopneas were defined as a >50% airflow reduction for ≥10 sec associated with a decrease of ≥3% in oxygen saturation [50]. Apnoeas were further categorized as mild (10 to 15 sec), moderate (15 to 30 sec), and severe (>30 sec) on the basis of their recorded duration. Legends: P-NPBI: plasma non-protein-bound iron; IE-NPBI: intraerythrocyte non-protein-bound iron; F₂-IsoPs: plasma F₂-isoprostanes; GSH: reduced glutathione; GSSG: oxidized glutathione.