Inflammatory Lung Disease in Rett Syndrome

Table 6

Frequency/severity of apneas, recorded during either the wakefulness or sleep, identifies Rett patients with increased intraerythrocyte non-protein-bound iron (IE-NPBI) levels: receiver operating characteristic (ROC) curves analyses.

Variable	AUC ± SE	95% C.I.	𝑃-value	Criterion	Sens.%	Spec.%	+LR	−LR	+PV	−PV
Total apneas/h	𝟎.𝟔𝟗𝟎±𝟎.𝟎𝟔𝟔𝟗	0.563–0.799	0.0044	>7.4	53.8	82.05	1.5	0.89	56.2	62.7
Mild apneas/h	0.634±0.0714	0.504–0.751	0.0605	>1	30.7	89.5	1.54	0.51	51.4	74.1
Moderate apneas/h	𝟎.𝟔𝟔𝟒±𝟎.𝟎𝟔𝟖𝟕	0.563–0.778	0.0163	>0.8	80.7	55.3	1.81	0.35	55.3	80.8
Severe apneas/h	𝟎.𝟔𝟕𝟎±𝟎.𝟎𝟔𝟗𝟑	0.541–0.782	0.0142	>2	50	81.6	2.71	0.61	65	70.5

AUC: area under the curve; SE: standard error; Sens.: sensitivity; Spec: specificity; +LR: positive likelihood ratio; −LR: negative likelihood ratio; +PV: positive predictive value; −PV: negative predictive value. Bold characters indicate statistically significant items.