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Mediators of Inflammation
Volume 2014 (2014), Article ID 564091, 8 pages
http://dx.doi.org/10.1155/2014/564091
Research Article

Changes in Cerebrospinal Fluid Biomarkers in Human Herpesvirus-6-Associated Acute Encephalopathy/Febrile Seizures

1Department of Pediatrics, Tokyo Metropolitan Fuchu Medical Center for the Disabled, 2-9-2 Musashidai, Fuchu, Tokyo 183-8553, Japan
2Department of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan
3Department of Pediatrics, School of Medicine, Juntendo University, Tokyo 113-8421, Japan
4Department of Neurology, National Center for Child Health and Development, Tokyo 157-8535, Japan
5Division of Neurology, Saitama Children’s Medical Center, Saitama 339-8551, Japan

Received 20 June 2014; Revised 2 September 2014; Accepted 3 September 2014; Published 11 September 2014

Academic Editor: Yung-Hsiang Chen

Copyright © 2014 Naoyuki Tanuma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Takanashi, H. Oba, A. J. Barkovich et al., “Diffusion MRI abnormalities after prolonged febrile seizures with encephalopathy,” Neurology, vol. 66, no. 9, pp. 1304–1309, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. J.-I. Takanashi, “Two newly proposed infectious encephalitis/encephalopathy syndromes,” Brain and Development, vol. 31, no. 7, pp. 521–528, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Hoshino, M. Saitoh, A. Oka et al., “Epidemiology of acute encephalopathy in Japan, with emphasis on the association of viruses and syndromes,” Brain and Development, vol. 34, no. 5, pp. 337–343, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Mizuguchi, “Overview of acute encephalitis and encephalopathy,” Nippon Rinsho. Japanese Journal of Clinical Medicine, vol. 69, no. 3, pp. 391–398, 2011. View at Google Scholar · View at Scopus
  5. M. Hayashi, “Oxidative stress in developmental brain disorders,” Neuropathology, vol. 29, no. 1, pp. 1–8, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Emerit, M. Edeas, and F. Bricaire, “Neurodegenerative diseases and oxidative stress,” Biomedicine and Pharmacotherapy, vol. 58, no. 1, pp. 39–46, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Dasuri, L. Zhang, and J. N. Keller, “Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis,” Free Radical Biology and Medicine, vol. 62, pp. 170–185, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Hayashi, N. Arai, J. Satoh et al., “Neurodegenerative mechanisms in subacute sclerosing panencephalitis,” Journal of Child Neurology, vol. 17, no. 10, pp. 725–730, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Hayashi, M. Itoh, S. Araki et al., “Oxidative stress and disturbed glutamate transport in hereditary nucleotide repair disorders,” Journal of Neuropathology & Experimental Neurology, vol. 60, no. 4, pp. 350–356, 2001. View at Google Scholar · View at Scopus
  10. M. Hayashi, S. Araki, J. Kohyama, K. Shioda, and R. Fukatsu, “Oxidative nucleotide damage and superoxide dismutase expression in the brains of xeroderma pigmentosum group A and Cockayne syndrome,” Brain and Development, vol. 27, no. 1, pp. 34–38, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Hayashi, S. Araki, N. Arai et al., “Oxidative stress and disturbed glutamate transport in spinal muscular atrophy,” Brain and Development, vol. 24, no. 8, pp. 770–775, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. E. Otomo, H. Tohgi, K. Kogure et al., “Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction: Randomized, placebo-controlled, double-blind study at multicenters,” Cerebrovascular Diseases, vol. 15, no. 3, pp. 222–229, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. B. J. Lee, Y. Egi, K. van Leyen, E. H. Lo, and K. Arai, “Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro,” Brain Research, vol. 1307, pp. 22–27, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Kitagawa, “Edaravone in acute ischemic stroke,” Internal Medicine, vol. 45, no. 5, pp. 225–226, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Higashi, “Edaravone for the treatment of acute cerebral infarction: role of endothelium-derived nitric oxide and oxidative stress,” Expert Opinion on Pharmacotherapy, vol. 10, no. 2, pp. 323–331, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Valyi-Nagy and T. S. Dermody, “Role of oxidative damage in the pathogenesis of viral infections of the nervous system,” Histology and Histopathology, vol. 20, no. 3, pp. 957–967, 2005. View at Google Scholar · View at Scopus
  17. T. Akaike, “Role of free radicals in viral pathogenesis and mutation,” Reviews in Medical Virology, vol. 11, no. 2, pp. 87–101, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Fukuda, H. Yamauchi, H. Yamamoto et al., “The evaluation of oxidative DNA damage in children with brain damage using 8-hydroxydeoxyguanosine levels,” Brain & Development, vol. 30, no. 2, pp. 131–136, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Tanuma, R. Miyata, S. Kumada et al., “The axonal damage marker tau protein in the cerebrospinal fluid is increased in patients with acute encephalopathy with biphasic seizures and late reduced diffusion,” Brain and Development, vol. 32, no. 6, pp. 435–439, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Öst, K. Nylén, L. Csajbok et al., “Initial CSF total tau correlates with 1-year outcome in patients with traumatic brain injury,” Neurology, vol. 67, no. 9, pp. 1600–1604, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Itoh, T. Satou, S. Nishida et al., “Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats,” Neurochemical Research, vol. 35, no. 2, pp. 348–355, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Ohta, Y. Higashi, T. Yawata et al., “Attenuation of axonal injury and oxidative stress by edaravone protects against cognitive impairments after traumatic brain injury,” Brain Research, vol. 1490, pp. 184–192, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Satoh and S. A. Lipton, “Redox regulation of neuronal survival mediated by electrophilic compounds,” Trends in Neurosciences, vol. 30, no. 1, pp. 37–45, 2007. View at Publisher · View at Google Scholar · View at Scopus