Changes in Cerebrospinal Fluid Biomarkers in Human Herpesvirus-6-Associated Acute Encephalopathy/Febrile Seizures

Table 3

Correlation analysis of CSF biomarkers in HHV-6 encephalopathy.

Biomarker		8-OHdG	HEL	Tau	IL-6	IL-10	TNF-
8-OHdG	Spearman	1.000	−0.292	−0.239	−0.484	−0.046	−0.315
		<0.0001	0.312	0.373	0.068	0.871	0.253
HEL	Spearman	−0.292	1.000	0.277	0.476	−0.286	0.497
		0.312	<0.0001	0.338	0.086	0.322	0.070
Tau	Spearman	−0.239	0.277	1.000	−0.036	−0.224	0.091
		0.373	0.338	<0.0001	0.899	0.422	0.748
IL-6	Spearman	−0.484	0.476	−0.036	1.000	0.226	0.783
		0.068	0.086	0.899	<0.0001	0.418	0.0006
Il-10	Spearman	−0.046	−0.286	−0.224	0.226	1.000	0.166
		0.871	0.322	0.422	0.418	<0.0001	0.555
TNF-	Spearman	−0.315	0.497	0.091	0.783	0.166	1.000
		0.253	0.070	0.748	0.0006	0.555	<0.0001

CSF: cerebrospinal fluid; HHV: human herpesvirus; 8-OHdG: 8-hydroxy-2′-deoxyguanosine; HEL: hexanoyl-lysine adduct; IL: interleukin; TNF: tumor necrosis factor.