Sphingosine-1-phosphate/S1P Receptors Signaling Modulates Cell Migration in Human Bone Marrow-Derived Mesenchymal Stem Cells

<table>S1P-induced migration of human BMSCs via cell surface receptor. (a) The representative images of serum-starved BMSC migration stimulated with BSA or 1 nM S1P for 4 h. (b)-(c) Serum-starved BMSCs were allowed to migrate for 4 h in the presence of varying concentrations of S1P and H<sub>2</sub>S1P, as indicated. Migrated cells in a random fields (b) or migration index (fold over basal, (c)) shown were counted in 10 random fields per filter for each condition. Data are presented as the mean ± SD. <svg height="17.825001" id="M3" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 66.324997 17.825001" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>, compared with control.</table>

Mediators of Inflammation

fig2

Figure 2

Figure 2: Sphingosine-1-phosphate/S1P Receptors Signaling Modulates Cell Migration in Human Bone Marrow-Derived Mesenchymal Stem Cells 