Figure 2: Soluble TWEAK predicts a progressive course of the disease in patients with dilated cardiomyopathy. (a) Receiver operating curve (ROC) analysis of baseline sTWEAK levels in patients with dilated cardiomyopathy revealed a cutoff value of 423 pg/mL for the prediction of death or heart transplantation on serial follow-up. Kaplan-Meier curves differed significantly between patients with a sTWEAK level below 423 pg/mL and those with an above level. (b) In those patients with significant deterioration during serial follow-up ( ), sTWEAK levels were already significantly reduced during the first visit. ROC analysis revealed a cutoff value of 588 pg/mL for the prediction of progressive symptoms ( ).