Palmitoleic Acid (N-7) Attenuates the Immunometabolic Disturbances Caused by a High-Fat Diet Independently of PPARα

Figure 1

Delta (Δ) of glucose uptake (a) and incorporation (b), variation in glycemia in the glucose tolerance test (c), and respective area under curve (AUC) (d). Variation in glycemia in the insulin tolerance test (e). Respective constants for glucose clearance (f) of WT mice fed with a standard diet (SD) or WT and PPARα-knockout (KO) mice subjected to a high-fat diet and treated with oleic acid (HFD) or palmitoleic acid (HFD PMA). The data are presented as mean ± SEM. ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃< 0.001 versus WT SD; ^#𝑃<0.05 HFD versus HFD PMA; and ^$$𝑃<0.01 and ^$$$𝑃<0.001 KO versus the respective WT control (one-way ANOVA followed by Bonferroni correction).

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