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Mediators of Inflammation
Volume 2014 (2014), Article ID 583409, 11 pages
http://dx.doi.org/10.1155/2014/583409
Research Article

Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment

1Upper Airway Research Laboratory (URL), Department of Otorhinolaryngology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium
2Department of Otolaryngology-Head and Neck Surgery, Federal University of São Paulo, Rua dos Otonis, 700 Piso Superior, Vila Clementino, 04025-002 São Paulo, SP, Brazil
3Nephrology Division, Department of Medicine, Federal University of São Paulo, 04025-002 São Paulo, SP, Brazil
4Department of Otorhinolaryngology and Ophthalmology, University of São Paulo, 05508-070 São Paulo, SP, Brazil
5Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, 05508-070 São Paulo, SP, Brazil

Received 21 August 2013; Revised 20 December 2013; Accepted 26 December 2013; Published 13 February 2014

Academic Editor: Bruno L. Diaz

Copyright © 2014 Rogério Pezato et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nasal polyposis is a severe, chronic inflammatory condition of the paranasal sinuses and is frequently associated with asthma and aspirin sensitivity. Mesenchymal stem cells exhibit a potent immunosuppressive effect in several inflammatory conditions, and their role in nasal polyposis remains little explored. Hence, we investigated whether bone marrow-derived mesenchymal stem cells could modulate cell phenotype in the nasal polyp milieu. After coculture with mesenchymal stem cells, the frequency of these inflammatory cells was found to decrease. Furthermore, mesenchymal stem cells promoted strong inhibition of CD4+ and CD8+ T cell proliferation, increased the frequency of CD4+CD25+Foxp3 T cells, and changed the global cytokine profile from an inflammatory to an anti-inflammatory response. We believe that mesenchymal stem cells may be a very useful adjunct for investigation of the inflammatory process in nasal polyposis, contributing to better understanding of the inflammatory course of this condition.