Research Article

Increased Peripheral Proinflammatory T Helper Subsets Contribute to Cardiovascular Complications in Diabetic Patients

Figure 1

Peripheral frequencies of Th22, Th1, and Th17 Cells were significantly higher in diabetic patients with CHD than those without CHD. Circulating percentages of CD4+ T cells in total lymphocytes as well as Th1, Th17, and Th22 cells in total CD4+ T cells from diabetic patients with (CHD group) or without coronary heart disease (non-CHD group). (a) There was no significant difference in percentages of CD4+ T cells between non-CHD and CHD group ( ). (b) Significant increases in Th1 were observed in CHD group ( %) compared to non-CHD group ( %) ( ). (c) Significantly elevated percentages of Th17 cells were also found in CHD group ( % versus %) ( ). (d) Elevations in Th22 cells in CHD were most remarkable ( % versus %) ( ). Bars represent SEM.