Increased Peripheral Proinflammatory T Helper Subsets Contribute to Cardiovascular Complications in Diabetic Patients
Peripheral frequencies of Th22, Th1, and Th17 Cells were significantly higher in diabetic patients with CHD than those without CHD. Circulating percentages of CD4+ T cells in total lymphocytes as well as Th1, Th17, and Th22 cells in total CD4+ T cells from diabetic patients with (CHD group) or without coronary heart disease (non-CHD group). (a) There was no significant difference in percentages of CD4+ T cells between non-CHD and CHD group (). (b) Significant increases in Th1 were observed in CHD group (%) compared to non-CHD group (%) (). (c) Significantly elevated percentages of Th17 cells were also found in CHD group (% versus %) (). (d) Elevations in Th22 cells in CHD were most remarkable (% versus %) (). Bars represent SEM.