Increased Peripheral Proinflammatory T Helper Subsets Contribute to Cardiovascular Complications in Diabetic Patients
Absolute numbers of Th22, Th1, and Th17 cells were significantly higher in diabetic patients with CHD than those without CHD. Absolute numbers of Th22, Th1, and Th17 cells as well as total CD4+ T cells. (a) Elevating tendency was observed but not statistically significant in absolute numbers of CD4+ T cells in CHD group (). (b) Significant increases in Th1 numbers were observed in CHD group () compared to non-CHD group () (). (c) Significantly elevated percentages of Th17 cells were also found in CHD group ( versus ) (). (d) Elevations in Th22 cells were more remarkable in CHD group ( versus ) (). Bars represent SEM.