Impact of Cyclosporine Levels on the Development of Acute Graft versus Host Disease after Reduced Intensity Conditioning Allogeneic Stem Cell Transplantation

Table 4

Univariate and multivariate analysis for aGVHD.

	Grade 2–4 aGVHD
Variable	Univariate analysis	Multivariate analysis
	𝑃	HR	CI 95%	𝑃
Sex-mismatch (female to male)	0.01	2.5	1.5–4.3	0.01
High CsA concentration
Second week	0.02			NS
Third week	0.01	0.99	0.98-0.99	0.03
Patient sex (male)	0.01			NS

The patients with median CsA levels higher than 150 ng/mL are included in the group “high CsA concentration.”
Notes: LR: log-rank; HR: hazard ratio; NS: not statistically significant.
CMV status, disease status at SCT, age of the recipient, conditioning regimen, immunosuppressive schedule, and CsA levels during the first and fourth week after transplantation were not associated with acute GVHD in univariate analysis (𝑃>0.1).