Impact of Cyclosporine Levels on the Development of Acute Graft versus Host Disease after Reduced Intensity Conditioning Allogeneic Stem Cell Transplantation

Table 5

Univariate and multivariate analysis for nonrelapse mortality and overall survival.

	Nonrelapse mortality			Overall survival
Variables	Univariate analysis	Multivariate cox regression		Univariate analysis	Multivariate cox regression
	𝑃 value	HR (95% CI)	𝑃	𝑃 value	HR (95% CI)	𝑃 value
Sex-mismatch (female to male)	<0.01		NS	0.02		NS
Advanced disease status	0.01	2.2 (1.3–4.3)	0.01	0.02	2.2 (1.1–4.3)	0.02
Low median CsA levels in 3rd week*	0.04		NS (0.06)	0.08		NS
Renal impairment*	0.06		NS	0.08		NS
Grade 2–4 aGVHD*	<0.01	2.5 (1.5–4.4)	0.01	<0.01	2.5 (1.4–4.4)	<0.01

Note: CsA: cyclosporine A; aGVHD: acute graft versus host disease; HR: hazard ratio; CI: confidence interval.
*Variables analyzed as time-dependent covariates.