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Mediators of Inflammation
Volume 2014, Article ID 627150, 13 pages
Research Article

Physical Exercise Reduces the Expression of RANTES and Its CCR5 Receptor in the Adipose Tissue of Obese Humans

1Department of Biomedical Research, Dasman Diabetes Institute, 1180 Dasman, Kuwait
2Queensland Children's Medical Research Institute, University of Queensland, Brisbane, QLD 4029, Australia
3Fitness and Rehabilitation Centre, Dasman Diabetes Institute, 1180 Dasman, Kuwait
4Department of Biostatistics and Epidemiology, Dasman Diabetes Institute, 1180 Dasman, Kuwait
5King Fahad Specialist Hospital, Dammam 15215, Saudi Arabia
6Diabetes Research Center, Qatar Biomedical Research Institute, Education City, P.O. Box 5825, Doha, Qatar

Received 19 December 2013; Accepted 30 March 2014; Published 17 April 2014

Academic Editor: Chiara De Luca

Copyright © 2014 Engin Baturcam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


RANTES and its CCR5 receptor trigger inflammation and its progression to insulin resistance in obese. In the present study, we investigated for the first time the effect of physical exercise on the expression of RANTES and CCR5 in obese humans. Fifty-seven adult nondiabetic subjects (17 lean and 40 obese) were enrolled in a 3-month supervised physical exercise. RANTES and CCR5 expressions were measured in PBMCs and subcutaneous adipose tissue before and after exercise. Circulating plasma levels of RANTES were also investigated. There was a significant increase in RANTES and CCR5 expression in the subcutaneous adipose tissue of obese compared to lean. In PBMCs, however, while the levels of RANTES mRNA and protein were comparable between both groups, CCR5 mRNA was downregulated in obese subjects (). Physical exercise significantly reduced the expression of both RANTES and CCR5 () in the adipose tissue of obese individuals with a concomitant decrease in the levels of the inflammatory markers TNF-α, IL-6, and P-JNK. Circulating RANTES correlated negatively with anti-inflammatory IL-1ra () and positively with proinflammatory IP-10 and TBARS levels (). Therefore, physical exercise may provide an effective approach for combating the deleterious effects associated with obesity through RANTES signaling in the adipose tissue.