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Mediators of Inflammation
Volume 2014, Article ID 629507, 10 pages
http://dx.doi.org/10.1155/2014/629507
Research Article

GSK-3β Inhibition Attenuates CLP-Induced Liver Injury by Reducing Inflammation and Hepatic Cell Apoptosis

1Department of Clinical Laboratory, Hubei Maternal and Child Health Hospital, Wuhan 430070, China
2Department of Infectious Diseases, Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China
3Department of Pathophysiology, Anhui Medical University, Hefei 230032, China
4Experimental Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, China
5Department of Molecular Medical Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
6Experimental Transplantation Surgery, Department of General, Visceral and Vascular Surgery, University Hospital of Jena, Friedrich-Schiller-University Jena, 07747 Jena, Germany

Received 11 July 2014; Accepted 25 October 2014; Published 30 November 2014

Academic Editor: Vera L. Petricevich

Copyright © 2014 Hui Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. E. Wang, N. I. Shapiro, D. C. Angus, and D. M. Yealy, “National estimates of severe sepsis in United States emergency departments,” Critical Care Medicine, vol. 35, no. 8, pp. 1928–1936, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. D. C. Angus, W. T. Linde-Zwirble, J. Lidicker, G. Clermont, J. Carcillo, and M. R. Pinsky, “Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care,” Critical Care Medicine, vol. 29, no. 7, pp. 1303–1310, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. V. Y. Dombrovskiy, A. A. Martin, J. Sunderram, and H. L. Paz, “Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003,” Critical Care Medicine, vol. 35, no. 5, pp. 1244–1250, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. G. S. Martin, D. M. Mannino, S. Eaton, and M. Moss, “The epidemiology of sepsis in the United States from 1979 through 2000,” The New England Journal of Medicine, vol. 348, no. 16, pp. 1546–1554, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Yan and S. Li, “The role of the liver in sepsis,” International Reviews of Immunology, vol. 33, no. 6, pp. 498–510, 2014. View at Publisher · View at Google Scholar
  6. J.-F. Dhainaut, N. Marin, A. Mignon, C. Vinsonneau, and C. Sprung, “Hepatic response to sepsis: Interaction between coagulation and inflammatory processes,” Critical Care Medicine, vol. 29, no. 7, pp. S42–S47, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Szabo, L. Romics Jr., and G. Frendl, “Liver in sepsis and systemic inflammatory response syndrome,” Clinics in Liver Disease, vol. 6, no. 4, pp. 1045–1066, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Kobashi, J. Toshimori, and K. Yamamoto, “Sepsis-associated liver injury: incidence, classification and the clinical significance,” Hepatology Research, vol. 43, no. 3, pp. 255–266, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Oberholzer, A. Oberholzer, M. Clare-Salzler, and L. L. Moldawer, “Apoptosis in sepsis: a new target for therapeutic exploration,” The FASEB Journal, vol. 15, no. 6, pp. 879–892, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. R. S. Hotchkiss, K. W. Tinsley, P. E. Swanson et al., “Prevention of lymphocyte cell death in sepsis improves survival in mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 25, pp. 14541–14546, 1999. View at Publisher · View at Google Scholar · View at Scopus
  11. R. S. Hotchkiss, P. E. Swanson, C. M. Knudson et al., “Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis,” Journal of Immunology, vol. 162, no. 7, pp. 4148–4156, 1999. View at Google Scholar · View at Scopus
  12. P. Cohen and M. Goedert, “GSK3 inhibitors: development and therapeutic potential,” Nature Reviews Drug Discovery, vol. 3, no. 6, pp. 479–487, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. G. V. Rayasam, V. K. Tulasi, R. Sodhi, J. A. Davis, and A. Ray, “Glycogen synthase kinase 3: more than a namesake,” British Journal of Pharmacology, vol. 156, no. 6, pp. 885–898, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Dugo, M. Collin, and C. Thiemermann, “Glycogen synthase kinase 3β as a target for the therapy of shock and inflammation,” Shock, vol. 27, no. 2, pp. 113–123, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Martin, K. Rehani, R. S. Jope, and S. M. Michalek, “Toll-like receptor—mediated cytokine production is differentially regulated by glycogen synthase kinase 3,” Nature Immunology, vol. 6, no. 8, pp. 777–784, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Dugo, M. Collin, D. A. Allen et al., “GSK-3β inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat,” Critical Care Medicine, vol. 33, no. 9, pp. 1903–1912, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. T. Chang, C. L. Chen, C. F. Lin et al., “Regulatory role of GSK-3β on NF-κB, nitric oxide, and TNF-α in group A streptococcal infection,” Mediators of Inflammation, vol. 2013, Article ID 720689, 10 pages, 2013. View at Publisher · View at Google Scholar
  18. P. Zhang, J. Katz, and S. M. Michalek, “Glycogen synthase kinase-3β (GSK3β) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice,” Molecular Immunology, vol. 46, no. 4, pp. 677–687, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Wang, W. C. Huang, C. Y. Wang et al., “Inhibiting glycogen synthase kinase-3 reduces endotoxaemic acute renal failure by down-regulating inflammation and renal cell apoptosis,” British Journal of Pharmacology, vol. 157, no. 6, pp. 1004–1013, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. L. Chen, F. Ren, H. Zhang et al., “Inhibition of glycogen synthase kinase 3β ameliorates D-GalN/LPS-induced liver injury by reducing endoplasmic reticulum stress-triggered apoptosis,” PLoS ONE, vol. 7, no. 9, Article ID e45202, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Liu, H. Fang, U. Dahmen, and O. Dirsch, “Chronic lithium treatment protects against liver ischemia/reperfusion injury in rats,” Liver Transplantation, vol. 19, no. 7, pp. 762–772, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. Y.-X. Xia, L. Lu, Z.-S. Wu, L.-Y. Pu, B.-C. Sun, and X.-H. Wang, “Inhibition of GSK-3β ameliorates hepatic ischemia-reperfusion injury through GSK-3β/β-catenin signaling pathway in mice,” Hepatobiliary and Pancreatic Diseases International, vol. 11, no. 3, pp. 278–284, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Ren, Z. Duan, Q. Cheng et al., “Inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury by way of an interleukin-10-mediated immune regulatory mechanism,” Hepatology, vol. 54, no. 2, pp. 687–696, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Liu, H. Fang, Y. Yang et al., “The fibrin-derived peptide Bβ15-42 attenuates liver damage in a rat model of liver ischemia/reperfusion injury,” Shock, vol. 39, no. 4, pp. 397–403, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Bohrer, F. Qiu, T. Zimmermann et al., “Role of NFκB in the mortality of sepsis,” The Journal of Clinical Investigation, vol. 100, no. 5, pp. 972–985, 1997. View at Google Scholar
  26. F. A. Bozza, J. I. Salluh, A. M. Japiassu et al., “Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis,” Critical Care, vol. 11, article R49, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. C. Pierrakos and J.-L. Vincent, “Sepsis biomarkers: a review,” Critical Care, vol. 14, no. 1, article R15, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. M. B. Everhart, W. Han, T. P. Sherrill et al., “Duration and intensity of NF-κB activity determine the severity of endotoxin-induced acute lung injury,” The Journal of Immunology, vol. 176, no. 8, pp. 4995–5005, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. X. Ye, J. Ding, X. Zhou, G. Chen, and F. L. Shu, “Divergent roles of endothelial NF-κB in multiple organ injury and bacterial clearance in mouse models of sepsis,” Journal of Experimental Medicine, vol. 205, no. 6, pp. 1303–1315, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Ding, D. Song, X. Ye, and S. F. Liu, “A pivotal role of endothelial-specific NF-κB signaling in the pathogenesis of septic shock and septic vascular dysfunction,” The Journal of Immunology, vol. 183, no. 6, pp. 4031–4038, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. R. F. Schwabe and D. A. Brenner, “Role of glycogen synthase kinase-3 in TNF-α-induced NF-κB activation and apoptosis in hepatocytes,” The American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 283, no. 1, pp. G204–G211, 2002. View at Google Scholar · View at Scopus