Involvement of Different CD4⁺ T Cell Subsets Producing Granzyme B in the Immune Response to Leishmania major Antigens

Table 1

Clinical and immunological features of the study population.

	HZCL Individuals (n = 15)	HC; (n = 13)
Age, mean ± SD (range), years	37.6 ± 12.9 (15–52)	27.6 ± 3.6 (22–33)
ZCL scars, yes/no	11/4	0/13
Male/female	6/9	2/11
LST induration, mean ± SD (range), mm	10.5 ± 4.6 (5–17.5)	Not available
LST positive^a	12/15	Not available
SLA-specific lymphoproliferation (IS)
mean ± SD (range)	31.8 ± 22 (8.8–78.2)	2.2 ± 0.6 (0.5–2.9)

ZCL: zoonotic cutaneous leishmaniasis; LST: leishmanin skin test; IS: index of stimulation.
^aNumber of individuals with a positive LST result/total number of tested individuals.