Effect of the Toll-Like Receptor 4 Antagonist Eritoran on Retinochoroidal Inflammatory Damage in a Rat Model of Endotoxin-Induced Inflammation

Table 1

TNF-𝛼, MDA, and NFκB levels of study groups.

Variable	Group 1 (control)	Group 2 (12 h) (LPS + saline)	Group 3 (24 h) (LPS + saline)	𝑃 value (group 2 versus 3)	Group 4 (12 h) (LPS + eritoran)	Group 5 (24 h) (LPS + eritoran)	𝑃 value (group 4 versus 5)	𝑃 value (group 1 versus 5)	𝑃 value (group 2 versus 4)	𝑃 value (group 3 versus 5)
Serum TNF-𝛼	19.90±2.89	32.50±4.48	39.40±7.55	0.008^a	28.20±5.43	25.20±5.59	0.069^a	0.139^c	0.112^c	<0.001^c
	(15.00–24.00)	(25.00–39.00)	(22.0–48.00)		(19.00–36.00)	(15.00–34.00)
Tissue TNF-𝛼	0.75, 0.43	2.15, 0.53	2.90, 0.80	0.004^b	2.15, 0.33	1.95, 0.43	0.057^b	<0.001^c	0.353^c	<0.001^c
	(0.30–1.00)	(1.90–2.70)	(2.20–3.60)		(1.70–2.40)	(1.40–2.90)
Serum MDA	8.00, 8.00	17.50, 5.50	29.00, 6.00	0.004^b	15.50, 4.75	13.00, 4.25	0.007^b	<0.001^c	0.105^c	<0.001^c
	(8.00-8.00)	(14.00–25.00)	(24.00–35.00)		(11.00–20.00)	(8.00–18.00)
Tissue MDA	9.94±1.71	24.50±6.75	28.40±4.74	0.003^a	22.50±4.62	20.00±3.80	0.002^a	<0.001^c	0.334^c	<0.001^c
	(7.70–12.10)	(20.00–34.00)	(21.00–37.00)		(16.00–30.00)	(15.00–27.00)
Tissue NFκB	0.30, 0.02	0.38, 0.03	0.41, 0.04	0.073^b	0.34, 0.05	0.31, 0.05	0.006^b	0.529^c	0.218^c	<0.001^c
	(0.27–0.32)	(0.32–0.77)	(0.35–0.46)		(0.28–0.37)	(0.24–0.36)

aPaired-sample 𝑡-test, bWilcoxon signed rank test, cMann-Whitney 𝑈 test.
TNF-𝛼: tumor necrosis factor-𝛼, MDA: malondialdehyde, NfκB: nuclear factor kappa B.
Data are presented as mean ± standard deviation (min–max) or median, interquartile range (min–max).