Paeonol (Pae) attenuates cigarette smoke- (CS-) induced lung inflammation in mice. Four groups of mice were chronically exposed to air or CS for 4 weeks. Two of the four study groups received daily treatment with paeonol (10 mg/kg body weight) or saline (vehicle control) by gastric gavage during the 4-week exposure. (a) Representative images of H&E stained lung sections. (b) Lung inflammatory scores were calculated according to the sum of the levels of cell infiltration and damage levels as assessed from the lung sections. ((c)–(e)) Total protein content, total cell count, and differential cell count in bronchoalveolar lavage fluid (BALF) were measured and served as indications of lung inflammation. Data in each group are mean ± SEM from 7 mice. versus the air-exposure group; versus the CS-exposure group with vehicle treatment.
