Table 1: Chemokines described in patients with MS.

Chemokine system nameHuman ligand (old name)Target cellsChemokine receptors

CCL2 [33]MCP-1T cells, NK cells, B cells, monocytes, and dendritic cellsCCR1, CCR2
CCL3 [36]MIP-1 T and B cells, macrophage, and neutrophilsCCR1, CCR4, CCR5
CCL4 [39]MIP-1 T cells, microglia, and macrophageCCR5
CCL5 [33]RANTEST cells, macrophage, eosinophils, and dendritic cellsCCR1, CCR3, CCR5
CCL7 [40]MCP-3T cells, B and NK cells, dendritic cells, and monocytesCCR1, CCR2, CCR3, CCR5
CCL8 [40]MCP-2T cells, monocytes, and dendritic cellsCCR1, CCR2, CCR3, CCR5
CCL11 [17]EotaxinT cells, dendritic cells, eosinophils, and basophilsCCR3
CCL17 [41]TARCT cellsCCR4
CCL19 [3]ELCT and B cells, and dendritic cellsCCR7
CCL20 [42]LARCT cells, monocytesCCR6
CCL21 [43]SLCT and NK cells, dendritic cellsCCR7
CXCL1 [40]GRO- monocytes, neutrophilsCXCR2
CXCL8 [41]IL-8monocytes, neutrophils, and fibroblastsCXCR1, CXCR2
CXCL9 [44]MIGT and NK cellsCXCR3
CXCL10 [45]IP-10T and NK cells, macrophages, and astrocytesCXCR3
CXCL11 [33]I-TACT and NK cellsCXCR3, CXCR7
CXCL12 [46]SDF-1T and B cells, dendritic cells, and monocytesCXCR4, CXCR7
CXCL13 [46]BCA-1T and B cells, dendritic cells, and monocytesCXCR5
CX3CL1 [47]FractalkineT and NK cells, monocytesCX3CR1