Chemokines and Chemokine Receptors in Multiple Sclerosis

Table 1

Chemokines described in patients with MS.

Chemokine system name	Human ligand (old name)	Target cells	Chemokine receptors
CCL2 [33]	MCP-1	T cells, NK cells, B cells, monocytes, and dendritic cells	CCR1, CCR2
CCL3 [36]	MIP-1𝛼	T and B cells, macrophage, and neutrophils	CCR1, CCR4, CCR5
CCL4 [39]	MIP-1𝛽	T cells, microglia, and macrophage	CCR5
CCL5 [33]	RANTES	T cells, macrophage, eosinophils, and dendritic cells	CCR1, CCR3, CCR5
CCL7 [40]	MCP-3	T cells, B and NK cells, dendritic cells, and monocytes	CCR1, CCR2, CCR3, CCR5
CCL8 [40]	MCP-2	T cells, monocytes, and dendritic cells	CCR1, CCR2, CCR3, CCR5
CCL11 [17]	Eotaxin	T cells, dendritic cells, eosinophils, and basophils	CCR3
CCL17 [41]	TARC	T cells	CCR4
CCL19 [3]	ELC	T and B cells, and dendritic cells	CCR7
CCL20 [42]	LARC	T cells, monocytes	CCR6
CCL21 [43]	SLC	T and NK cells, dendritic cells	CCR7
CXCL1 [40]	GRO-𝛼	monocytes, neutrophils	CXCR2
CXCL8 [41]	IL-8	monocytes, neutrophils, and fibroblasts	CXCR1, CXCR2
CXCL9 [44]	MIG	T and NK cells	CXCR3
CXCL10 [45]	IP-10	T and NK cells, macrophages, and astrocytes	CXCR3
CXCL11 [33]	I-TAC	T and NK cells	CXCR3, CXCR7
CXCL12 [46]	SDF-1	T and B cells, dendritic cells, and monocytes	CXCR4, CXCR7
CXCL13 [46]	BCA-1	T and B cells, dendritic cells, and monocytes	CXCR5
CX3CL1 [47]	Fractalkine	T and NK cells, monocytes	CX3CR1