Angiogenesis-Related Biomarkers in Patients with Alcoholic Liver Disease: Their Association with Liver Disease Complications and Outcome

Table 4

Plasma angiogenesis-related biomarkers in subgroups of patients with different grades of liver failure.

(a) CTP class

	Class A (𝑛=30)			Class B (𝑛=73)			Class C (𝑛=44)			𝑃
	Median	95% CI	25–75 P	Median	95% CI	25–75 P	Median	95% CI	25–75 P
Ang1; ng/mL	2.96	1.81–3.26	1.16–5.06	3.17	1.98–4.72	1.03–6.20	2.08	1.02–3.66	0.00–4.65	0.28
Ang2; ng/mL	2.94	2.35–3.85	1.88–3.99	4.56	3.57–5.35	2.91–7.23	10.32	9.42–11.86	5.12–13.44	<0.0001
VEGF-A; pg/mL	100.13	73.50–120.66	62.57–231.66	89.21	61.40–203.16	30.60–358.15	67.21	48.27–81.25	33.74–112.68	0.07

(b) MELD score

	<20 points (𝑛=117)			≥20 points (𝑛=30)			𝑃
	Median	95% CI	25–75 P	Median	95% CI	25–75 P
Ang1; ng/mL	2.90	2.09–3.36	1.03–5.84	2.71	0.11–3.72	0.00–5.1	0.16
Ang2; ng/mL	3.90	3.56–4.56	2.86–7.72	11.37	7.05–13.19	5.12–15.94	<0.0001
VEGF-A; pg/mL	86.55	71.81–100.18	43.10–207.91	64.60	27.11–148.12	23.25–246.83	0.20