Angiogenesis-Related Biomarkers in Patients with Alcoholic Liver Disease: Their Association with Liver Disease Complications and Outcome
Table 6
Comparison of the diagnostic accuracy (AUC) of single variables in the diagnosis of advanced liver dysfunction (MELD ≥ 20) and ALD complications (univariable analysis).
Complication of ALD
Variable
value
AUC (95% CI)
SE
MELD ≥ 20
Ang2
<0.0001
0.829 (0.758–0.886)
0.036
CRP
0.004
0.609 (0.527–0.686)
0.058
RBC
0.003
0.675 (0.596–0.747)
0.055
WBC
0.0003
0.656 (0.577–0.730)
0.061
Ascites
0.003
0.652 (0.572–0.725)
0.050
HE
<0.0001
0.666 (0.587–0.739)
0.058
Ascites
Ang2
<0.0001
0.772 (0.695–0.837)
0.041
Albumin
<0.0001
0.819 (0.748–0.877)
0.036
ALT
0.0001
0.710 (0.633–0.779)
0.041
AST
0.003
0.606 (0.526–0.683)
0.047
INR
<0.0001
0.808 (0.739–0.866)
0.036
RBC
0.002
0.663 (0.584–0.736)
0.044
WBC
0.008
0.597 (0.517–0.674)
0.045
HE
Ang2
0.0001
0.731 (0.652–0.801)
0.063
VEGF-A
0.022
0.705 (0.624–0.777)
0.050
AP
0.006
0.652 (0.567–0.730)
0.071
Albumin
0.005
0.686 (0.605–0.759)
0.055
T-bilirubin
0.0001
0.770 (0.697–0.833)
0.048
INR
0.0001
0.737 (0.661–0.804)
0.059
PLT
0.035
0.633 (0.553–0.708)
0.057
Ascites
0.012
0.646 (0.567–0.720)
0.056
Renal impairment (crea > 1.3 mg/dL)
Ang2
0.003
0.692 (0.610–0.765)
0.062
Albumin
0.034
0.654 (0.572–0.729)
0.059
AST
0.042
0.601 (0.521–0.678)
0.062
AP
0.030
0.677 (0.593–0.753)
0.068
Na
0.012
0.588 (0.508–0.666)
0.080
CRP
0.001
0.714 (0.636–0.784)
0.060
WBC
0.011
0.689 (0.611–0.760)
0.053
RBC
0.031
0.688 (0.610–0.759)
0.059
Poor outcome (nonsurvival)
Ang2
0.009
0.788 (0.713–0.851)
0.059
Bilirubin
0.0004
0.765 (0.691–0.828)
0.059
Albumin
0.0004
0.818 (0.747–0.876)
0.061
Na
0.003
0.751 (0.676–0.816)
0.081
AP
0.024
0.641 (0.556–0.720)
0.102
INR
0.009
0.735 (0.659–0.802)
0.057
HE
0.005
0.652 (0.573–0.726)
0.086
AUC: area under the ROC curve; CI: confidence interval; SE: standard error.
