Angiogenesis-Related Biomarkers in Patients with Alcoholic Liver Disease: Their Association with Liver Disease Complications and Outcome

Table 7

Independent predictors of advanced liver dysfunction (MELD ≥ 20) and ALD complications (multivariable analysis)∗.

Complication of ALD	Variable	𝑃 value	Adjusted OR (95% CI)	AUC (95% CI)	SE
MELD ≥ 20	Ang2	<0.0001	1.358 (1.190–1.550)	0.908 (0.844–0.952)	0.028
	HE	0.021	4.796 (1.269–18.124)
HE	Ang2	0.010	1.256 (1.057–1.493)	0.934 (0.876–0.970)	0.029
	VEGF-A	0.066	0.977 (0.953–1.002)
	AP	0.035	1.016 (1.001–1.032)
	T-bilirubin	0.024	1.126 (1.015–1.249)
	PLT	0.014	0.980 (0.965–0.996)
Renal impairment; (crea > 1.3 mg/dL)	Ang2	0.009	1.128 (1.030–1.236)	0.775 (0.695–0.842)	0.060
	CRP	0.006	1.023 (1.006–1.039)

∗AUC: area under the ROC curve; CI: confidence interval; Crea: creatinine; HE: hepatic encephalopathy; OR: odds ratio; SE: standard error.