Mediators of Inflammation

Research Article

Differential Associations of Inflammatory and Endothelial Biomarkers with Disease Activity in Rheumatoid Arthritis of Short Duration

Table 1

Clinical characteristics and traditional cardiovascular (CV) risk factors of RA patients and control subjects.


	RA patients ()		Control group ()		P value	P adjusted^a
	Nv	Mean (SD)	Nv	Mean (SD)	P value	P adjusted^a

Clinical characteristics
Age, years	29	40.96 (9.45)	29	31.65 (7.64)	<0.001
Female gender, (%)	29	22 (76%)	29	13 (45%)	0.030
Smoking habit, number (%)	28	12 (43%)	29	5 (17%)	0.045
Positive family history of premature CVD, number (%)	28	15 (54%)	29	6 (21%)	0.013
RF positivity, n (%)	29	25 (86%)	—		NA
aCCP positivity, (%)	28	24 (83%)	—	—	NA
Disease duration, months	29	12 [4; 18]	—	—	NA
DAS28	29	4.45 (1.53)	—	—	NA
Steroids, number (%)	29	11 (38%)	—	—	NA
NSAIDs, number (%)	29	19 (65%)	—	—	NA
Antihypertensives, number (%)	29	2 (7%)	29	0	0.236
Traditional CV risk factors
Systolic blood pressure, mmHg	29	120.79 (17.95)	28	114.96 (12.78)	0.164	0.872
Diastolic blood pressure, mmHg	29	79.86 (7.72)	28	76.75 (6.76)	0.131	0.825
Mean arterial pressure, mmHg	29	93.5 (10.31)	28	89.48 (7.98)	0.106	0.850
Body mass index, kg/m²	28	23.45 (4.04)	29	23.24 (2.63)	0.909	0.427
Waist circumference (cm)	28	78.6 (10.13)	28	80.67 (10.92)	0.435	0.149
Glucose, mmol/L	29	4.63 (0.4)	29	4.73 (0.46)	0.366	0.142
TC, mmol/L	27	5.01 (1.2)	28	5.03 (0.73)	0.937	0.005
LDL-C, mmol/L	26	3.07 (0.92)	28	2.85 (0.8)	0.366	0.129
HDL-C, mmol/L	26	1.53 (0.42)	28	1.71 (0.49)	0.160	0.018
Triglycerides, mmol/L	26	0.98 (0.47)	28	1.02 (0.54)	0.924	0.450
Creatinine, µmol/L	29	59.27 (10.08)	29	69.76 (9.67)	<0.001	0.008
eGFR, mL/min per 1.73 m²of BSA	29	113.11 (25.19)	29	107.68 (17.23)	0.340	0.009
Fibrinogen, g/L	29	4.03 (1.51)	29	2.98 (0.7)	0.001	0.011
Homocysteine, µmol/L	29	10.28 (4.62)	27	10.56 (4.33)	0.571	0.804
Cystatin C, mg/L	29	0.72 (0.16)	26	0.53 (0.1)	<0.001	<0.001

Data are shown as unadjusted means (SD) or medians [interquartile range, IRQ] or percentages (%). Nv: valid cases; NA: not applicable; RA: rheumatoid arthritis; RF: rheumatoid factor; aCCP: anti-cyclic citrullinated peptide antibodies; DAS28: disease activity score in 28 joints; NSAIDs: nonsteroidal anti-inflammatory drugs; CVD: cardiovascular disease; TC: total cholesterol; LDL-C: low-density lipoproteins-cholesterol; HDL-C: high-density lipoproteins-cholesterol; eGFR: estimated glomerular filtration rate; BSA: body surface area.
^aAge-sex adjusted P value for the defining groups of patients in ANOVA (GLM models)—type III sum of square (SS) was used.