LPS-Challenged TNFα Production, Prostaglandin Secretion, and TNFα/TNFRs Expression in the Endometrium of Domestic Cats in Estrus or Diestrus, and in Cats with Pyometra or Receiving Medroxyprogesterone Acetate
Figure 5
TNFα protein localization in endometria. Immunohistochemical (IHC) localization of TNFα in the endometria of cats collected at (a) estrus phase (E; ) and (b) diestrus phase (D, ) from (c) cats that had been treated with a P4 derivative analog, medroxyprogesterone acetate (MPA, ; (d) cats presenting the clinical symptoms of pyometra (PYO, ). (a) In females at estrus, strong TNFα signals are localized in glandular and surface epithelium; (b) in females at diestrus, some weak signals are localized in endometrial stroma; (c) in MPA females, TNFα expression is localized mostly in deep glands and weaker signals are present in surface epithelium; (d) in PYO females, signals are mostly localized in both the surface and the glandular epithelium. Surface epithelium: white arrowheads; glandular epithelium: white arrows; endometrial stroma: black arrows.
