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Mediators of Inflammation
Volume 2014, Article ID 709024, 8 pages
http://dx.doi.org/10.1155/2014/709024
Clinical Study

Association between Parathyroid Hormone Levels and Inflammatory Markers among US Adults

1Department of Surgery, Mackay Memorial Hospital and Mackay Medical College, 92 Chung-Shan North Road, Section 2, Taipei 10449, Taiwan
2Mackay Junior College of Medicine, Nursing and Management, 92 Shengjing Road, Taipei 11260, Taiwan
3Department of Pharmacology and Graduate Institute of Medical Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan
4Institute of Statistical Science, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 11529, Taiwan

Received 11 December 2013; Accepted 27 February 2014; Published 23 March 2014

Academic Editor: Dianne Cooper

Copyright © 2014 Shih-Ping Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Silver, M. Rodriguez, and E. Slatopolsky, “FGF23 and PTH—double agents at the heart of CKD,” Nephrology Dialysis Transplantation, vol. 27, pp. 1715–1720, 2012. View at Google Scholar
  2. S. B. Kritchevsky, J. A. Tooze, R. H. Neiberg et al., “Health ABC Study. 25-Hydroxyvitamin D, parathyroid hormone, and mortality in black and white older adults: the health ABC study,” Journal of Clinical Endocrinology & Metabolism, vol. 97, pp. 4156–4165, 2012. View at Google Scholar
  3. A. J. van Ballegooijen, I. Reinders, M. Visser et al., “Serum parathyroid hormone in relation to all-cause and cardiovascular mortality: the Hoorn study,” Journal of Clinical Endocrinology & Metabolism, vol. 98, pp. E638–E645, 2013. View at Google Scholar
  4. J. S. Chen, P. N. Sambrook, L. March et al., “Hypovitaminosis D and parathyroid hormone response in the elderly: effects on bone turnover and mortality,” Clinical Endocrinology, vol. 68, no. 2, pp. 290–298, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Gandhi and R. B. Myers, “Can parathyroid hormone be used as a biomarker for heart failure?” Heart Failure Reviews, vol. 18, pp. 465–473, 2013. View at Google Scholar
  6. C. W. G. M. Lowik, G. van der Pluijm, H. Bloys et al., “Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: a possible role of interleukin-6 in osteoclastogenesis,” Biochemical and Biophysical Research Communications, vol. 162, no. 3, pp. 1546–1552, 1989. View at Google Scholar · View at Scopus
  7. M. A. Mitnick, A. Grey, U. Masiukiewicz et al., “Parathyroid hormone induces hepatic production of bioactive interleukin-6 and its soluble receptor,” American Journal of Physiology: Endocrinology and Metabolism, vol. 280, no. 3, pp. E405–E412, 2001. View at Google Scholar · View at Scopus
  8. J. V. Castell, M. J. Gomez-Lechon, M. David et al., “Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes,” FEBS Letters, vol. 242, no. 2, pp. 237–239, 1989. View at Publisher · View at Google Scholar · View at Scopus
  9. J. V. Castell, M. J. Gomez-Lechon, M. David, R. Fabra, R. Trullenque, and P. C. Heinrich, “Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6,” Hepatology, vol. 12, no. 5, pp. 1179–1186, 1990. View at Publisher · View at Google Scholar · View at Scopus
  10. M. F. McCarty, “Secondary hyperparathyroidism promotes the acute phase response—a rationale for supplemental Vitamin D in prevention of vascular events in the elderly,” Medical Hypotheses, vol. 64, no. 5, pp. 1022–1026, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Grey, M.-A. Mitnick, S. Shapses, A. Ellison, C. Gundberg, and K. Insogna, “Circulating levels of interleukin-6 and tumor necrosis factor-α are elevated in primary hyperparathyroidism and correlate with markers of bone resorption—a clinical research center study,” Journal of Clinical Endocrinology and Metabolism, vol. 81, no. 10, pp. 3450–3454, 1996. View at Publisher · View at Google Scholar · View at Scopus
  12. C.-Y. Guo, P. A. Holland, B. F. Jackson et al., “Immediate changes in biochemical markers of bone turnover and circulating interleukin-6 after parathyroidectomy for primary hyperparathyroidism,” European Journal of Endocrinology, vol. 142, no. 5, pp. 451–459, 2000. View at Google Scholar · View at Scopus
  13. C. G. Øgard, M. D. Engelmann, C. Kistorp, S. L. Nielsen, and H. Vestergaard, “Increased plasma N-terminal pro-B-type natriuretic peptide and markers of inflammation related to atherosclerosis in patients with primary hyperparathyroidism,” Clinical Endocrinology, vol. 63, no. 5, pp. 493–498, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. A. A. Emam, S. G. Mousa, K. Y. Ahmed, and A. A. Al-Azab, “Inflammatory biomarkers in patients with asymptomatic primary hyperparathyroidism,” Medical Principles and Practice, vol. 21, no. 3, pp. 249–253, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Chertok-Shacham, A. Ishay, I. Lavi, and R. Luboshitzky, “Biomarkers of hypercoagulability and inflammation in primary hyperparathyroidism,” Medical Science Monitor, vol. 14, no. 12, pp. CR628–CR632, 2008. View at Google Scholar · View at Scopus
  16. P. Farahnak, G. Lärfars, M. Sten-Linder, and I.-L. Nilsson, “Mild primary hyperparathyroidism: vitamin D deficiency and cardiovascular risk markers,” Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 7, pp. 2112–2118, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Halabe and B. Shohat, “Effect of parathyroid adenoma excision on interleukin-6 (IL-6) and IL-2 receptor levels,” Metabolism: Clinical and Experimental, vol. 49, no. 2, pp. 192–194, 2000. View at Google Scholar · View at Scopus
  18. E. G. Almqvist, A.-G. Bondeson, L. Bondeson, and J. Svensson, “Increased markers of inflammation and endothelial dysfunction in patients with mild primary hyperparathyroidism,” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 71, no. 2, pp. 139–144, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Bollerslev, T. Rosen, C. L. Mollerup et al., “Effect of surgery on cardiovascular risk factors in mild primary hyperparathyroidism,” Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 7, pp. 2255–2261, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. G. Zhao, E. S. Ford, C. Li, P. M. Kris-Etherton, T. D. Etherton, and L. S. Balluz, “Independent associations of serum concentrations of 25-hydroxyvitamin D and parathyroid hormone with blood pressure among US adults,” Journal of Hypertension, vol. 28, no. 9, pp. 1821–1828, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. C. L. Liu, J. J. Lee, T. P. Liu, Y. C. Chang, Y. C. Hsu, and S. P. Cheng, “Blood neutrophil-to-lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer,” Journal of Surgical Oncology, vol. 107, pp. 493–497, 2013. View at Google Scholar
  22. “Centers for Disease Control and Prevention,” National Health and Nutrition Examination Survey 2003-2004, http://wwwn.cdc.gov/nchs/nhanes/search/nhanes03_04.aspx.
  23. Centers for Disease Control and Prevention, National Health and Nutrition Examination Survey 2005-2006, http://wwwn.cdc.gov/nchs/nhanes/search/nhanes05_06.aspx.
  24. A. S. Levey, L. A. Stevens, C. H. Schmid et al., “CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). A new equation to estimate glomerular filtration rate,” Annals of Internal Medicine, vol. 150, pp. 604–612, 2009. View at Google Scholar
  25. D. C. McMillan, “The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer,” Cancer Treatment Reviews, vol. 39, pp. 534–540, 2013. View at Google Scholar
  26. M. Rodriguez and V. Lorenzo, “Parathyroid hormone, a uremic toxin,” Seminars in Dialysis, vol. 22, no. 4, pp. 363–368, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. S. P. Cheng, J. J. Lee, T. P. Liu et al., “Parathyroidectomy improves symptomatology and quality of life in patients with secondary hyperparathyroidism,” Surgery, vol. 155, pp. 320–328, 2014. View at Google Scholar
  28. E. Hagström, P. Hellman, T. E. Larsson et al., “Plasma parathyroid hormone and the risk of cardiovascular mortality in the community,” Circulation, vol. 119, no. 21, pp. 2765–2771, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. P. M. Cawthon, N. Parimi, E. Barrett-Connor et al., “Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 10, pp. 4625–4634, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. N. R. Caron and J. L. Pasieka, “What symptom improvement can be expected after operation for primary hyperparathyroidism?” World Journal of Surgery, vol. 33, no. 11, pp. 2244–2255, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. M. H. E. Christensen, S. N. Dankel, Y. Nordbø et al., “Primary hyperparathyroidism influences the expression of inflammatory and metabolic genes in adipose tissue,” PLoS ONE, vol. 6, no. 6, Article ID e20481, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Lütfioǧlu, U. Sakallioǧlu, E. E. Sakallioǧlu, E. Diraman, G. Çiftçi, and F. Tutkun, “Dietary-induced hyperparathyroidism affects serum and gingival proinflammatory cytokine levels in rats,” Journal of Periodontology, vol. 81, no. 1, pp. 150–157, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. R. Alemzadeh and J. Kichler, “Parathyroid hormone is associated with biomarkers of insulin resistance and inflammation, independent of vitamin D status, in obese adolescents,” Metabolic Syndrome and Related Disorders, vol. 10, pp. 422–429, 2012. View at Google Scholar
  34. J. Hjelmesæth, D. Hofsø, E. T. Aasheim et al., “Parathyroid hormone, but not vitamin D, is associated with the metabolic syndrome in morbidly obese women and men: a cross-sectional study,” Cardiovascular Diabetology, vol. 8, article 7, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. O. Yousuf, B. D. Mohanty, S. S. Martin et al., “High-sensitivity C-reactive protein and cardiovascular disease: a resolute belief or an elusive link?” Journal of the American College of Cardiology, vol. 62, pp. 397–408, 2013. View at Google Scholar
  36. K. H. Allin and B. G. Nordestgaard, “Elevated C-reactive protein in the diagnosis, prognosis, and cause of cancer,” Critical Reviews in Clinical Laboratory Sciences, vol. 48, no. 4, pp. 155–170, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. G. Lippi, G. Targher, M. Montagnana, G. L. Salvagno, G. Zoppini, and G. C. Guidi, “Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients,” Archives of Pathology & Laboratory Medicine, vol. 133, pp. 628–632, 2009. View at Google Scholar
  38. T. S. Perlstein, J. Weuve, M. A. Pfeffer, and J. A. Beckman, “Red blood cell distribution width and mortality risk in a community-based prospective cohort,” Archives of Internal Medicine, vol. 169, no. 6, pp. 588–594, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. Z. Förhécz, T. Gombos, G. Borgulya, Z. Pozsonyi, Z. Prohászka, and L. Jánoskuti, “Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state,” American Heart Journal, vol. 158, no. 4, pp. 659–666, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. K. V. Patel, R. D. Semba, L. Ferrucci et al., “Red Cell distribution width and mortality in older adults: a meta-analysis,” Journals of Gerontology A: Biological Sciences and Medical Sciences, vol. 65, no. 3, pp. 258–265, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. M. H. F. Klinger and W. Jelkmann, “Role of blood platelets in infection and inflammation,” Journal of Interferon and Cytokine Research, vol. 22, no. 9, pp. 913–922, 2002. View at Publisher · View at Google Scholar · View at Scopus
  42. R. A. Smith, L. Bosonnet, P. Ghaneh et al., “The platelet-lymphocyte ratio improves the predictive value of serum CA19-9 levels in determining patient selection for staging laparoscopy in suspected periampullary cancer,” Surgery, vol. 143, no. 5, pp. 658–666, 2008. View at Publisher · View at Google Scholar · View at Scopus
  43. B. Azab, N. Shah, M. Akerman, and J. T. McGinn Jr., “Value of platelet/lymphocyte ratio as a predictor of all-cause mortality after non-ST-elevation myocardial infarction,” Journal of Thrombosis and Thrombolysis, vol. 34, pp. 326–334, 2012. View at Publisher · View at Google Scholar · View at Scopus
  44. K. Turkmen, F. M. Erdur, F. Ozcicek et al., “Platelet-to-lymphocyte ratio better predicts inflammation than neutrophil-to-lymphocyte ratio in end-stage renal disease patients,” Hemodialysis International, vol. 17, pp. 391–396, 2013. View at Google Scholar
  45. A. Benigni, M. Livio, and P. Dodesini, “Inhibition of human platelet aggregation by parathyroid hormone. Is cyclic AMP implicated?” American Journal of Nephrology, vol. 5, no. 4, pp. 243–247, 1985. View at Google Scholar · View at Scopus
  46. D. Fliser, E. Franek, P. Fode et al., “Subacute infusion of physiological doses of parathyroid hormone raises blood pressure in humans,” Nephrology Dialysis Transplantation, vol. 12, no. 5, pp. 933–938, 1997. View at Publisher · View at Google Scholar · View at Scopus
  47. A. S. Geara, M. R. Castellanos, C. Bassil et al., “Effects of parathyroid hormone on immune function,” Clinical and Developmental Immunology, vol. 2010, Article ID 418695, 10 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  48. M. J. Proctor, D. S. Morrison, D. Talwar et al., “A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study,” European Journal of Cancer, vol. 47, no. 17, pp. 2633–2641, 2011. View at Publisher · View at Google Scholar · View at Scopus
  49. J. Munoz Mendoza, T. Isakova, A. C. Ricardo et al., “Chronic renal insufficiency cohort. Fibroblast growth factor 23 and Inflammation in CKD,” Clinical Journal of the American Society of Nephrology, vol. 7, pp. 1155–1162, 2012. View at Google Scholar
  50. M. C. Izquierdo, M. V. Perez-Gomez, M. D. Sanchez-Nino et al., “Klotho, phosphate and inflammation/ageing in chronic kidney disease,” Nephrology Dialysis Transplantation, vol. 27, supplement 4, pp. iv6–i10, 2012. View at Google Scholar
  51. M. D. Kearns, J. A. Alvarez, and V. Tangpricha, “Large, single-dose, oral vitamin D supplementation in adult populations: a systematic review,” Endocrine Practice, vol. 18, pp. 1–36. View at Publisher · View at Google Scholar