Association between Parathyroid Hormone Levels and Inflammatory Markers among US Adults
Table 2
Weighted mean values and the regression coefficients with standard errors (SEs) for C-reactive protein, red blood cell distribution width, and platelet-to-lymphocyte ratio by serum parathyroid hormone (PTH) levels among the United States adults aged at least 20 years, NHANES 2003–2006.
Mean (SE)
Regression coefficient (SE)
Model 1
Model 2
Model 3
Model 4
C-reactive protein (mg/dL)
PTH group (pg/mL)
6–39
0.47 (0.01)
0
0
0
0
40–59
0.47 (0.02)
0.021 (0.044)
0.041 (0.044)
0.089 (0.040)
0.088 (0.038)
60–99
0.55 (0.02)
0.162 (0.032)
0.195 (0.034)
0.189 (0.035)
0.183 (0.037)
100–1491
0.75 (0.07)
0.339 (0.068)
0.363 (0.066)
0.194 (0.065)
0.175 (0.068)
value for trend
<0.001
<0.001
<0.001
<0.001
Continuous PTH
0.085 (0.031)
0.109 (0.031)
0.139 (0.029)
0.138 (0.031)
value
0.011
0.001
<0.001
<0.001
Red blood cell distribution width (%)
PTH group (pg/mL)
6–39
12.72 (0.02)
0
0
0
0
40–59
12.87 (0.02)
0.069 (0.022)
0.087 (0.022)
0.106 (0.020)
0.057 (0.022)
60–99
13.16 (0.04)
0.320 (0.039)
0.337 (0.040)
0.332 (0.038)
0.239 (0.040)
100–1491
13.68 (0.08)
0.770 (0.085)
0.757 (0.087)
0.667 (0.086)
0.504 (0.084)
value for trend
<0.001
<0.001
<0.001
<0.001
Continuous PTH
0.299 (0.032)
0.315 (0.032)
0.322 (0.032)
0.231 (0.031)
value
<0.001
<0.001
<0.001
<0.001
Platelet-to-lymphocyte ratio
PTH group (pg/mL)
6–39
138.0 (1.2)
0
0
0
0
40–59
139.0 (1.1)
−0.752 (1.171)
−1.674 (1.226)
−1.007 (1.253)
−0.480 (1.324)
60–99
142.6 (1.0)
1.778 (1.200)
0.399 (1.238)
0.713 (1.336)
1.059 (1.565)
100–1491
153.9 (3.9)
11.7462 (3.603)
9.641 (3.542)
9.353 (3.770)
7.454 (4.271)
value for trend
0.004
0.114
0.085
0.190
Continuous PTH
3.183 (0.962)
1.679 (1.030)
2.193 (1.086)
2.444 (1.416)
value
0.002
0.114
0.052
0.095
Linear regression analyses were conducted using serum PTH as both categorical and continuous variable. Model 1: adjusted for age and sex; Model 2: adjusted for age, sex, race/ethnicity, smoking status, and glycohemoglobin levels (continuous); Model 3: adjusted for variables in Model 2 plus albumin, triglycerides, and high-density lipoprotein levels (all continuous); Model 4: adjusted for variables in Model 3 plus corrected total calcium, 25-hydroxyvitamin D, and estimated glomerular filtration rate (all continuous).
