The Roles of CD147 and/or Cyclophilin A in Kidney Diseases

Figure 2

A schematic representation of a proposed mechanism implicated in CyPA/CD147-mediated cell response in AKI. CyPA is overexpressed after CLP and renal dysfunction is significantly attenuated by anti-CD147 antibody intraperitoneally. Specific inhibitor against CyPA might also improve the renal function. CD147 may result in activation of ERK1/2 and NF-kB, involved in cell apoptosis, proliferation, and the product of cytokines and MMPs.