Effect of Sipjeondaebo-Tang on Cancer-Induced Anorexia and Cachexia in CT-26 Tumor-Bearing Mice

Figure 6

Schematic illustration. To set up the tumor burden cachexia mice model, mice were injected s.c. with CT-26 tumor cells. 21 days after tumor cell injection, three doses of SJDBT (L-SJDBT, M-SJDBT, and H-SJDBT) and MA were p.o. added daily. After treatment with indications for 21 days, mice were sacrificed and blood samples were analyzed for blood analysis and cytokines and hormones level in serum. SJDBT improved cancer cachexia in mice and inhibited the production of IL-6, MCP-1, PYY, and GLP-1. Therefore, we conclude that SJDBT improves cancer-induced cachexia including weight loss, anorexia, muscle wasting, anemia, and dysregulation of cytokines and hormones.