Circulating Th17, Th22, and Th1 Cells Are Elevated in the Guillain-Barré Syndrome and Downregulated by IVIg Treatments

Figure 3

The correlations of circulating CD4⁺IFN-𝛾⁺, CD4⁺IL-22⁺, Th1 (IFN-𝛾⁺IL-17A⁻IL-22⁻), Th1/Th17 (IFN-𝛾⁺IL-17A⁺IL-22⁻), Th17 (CD4⁺IL-17A⁺, IFN-𝛾⁻IL-17A⁺IL-22⁻, and IFN-𝛾⁻IL-17A⁺IL-22⁺), and Th22 (IFN-𝛾⁻IL-17A⁻IL-22⁺) cells on CD4⁺ cells with GBS disability scale scores (GDSs). Dot plot of Th22 cells and GDSs of GBS patients illustrated their correlation (𝑃<0.05) (h). Dot plot of CD4⁺IL-22⁺ cells had an elevated tendency with higher GDSs (c). The Spearman correlation coefficient was used to differentiate between two sets. Each circle = single individual; lines = linear approximation.

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