Anti-Inflammatory Functions of Protein C Require RAGE and ICAM-1 in a Stimulus-Dependent Manner
Figure 4
Effect of PC treatment on bronchoalveolar neutrophil emigration during LPS-induced ALI in wild-type, RAGE , and Icam-1 mice. In a 6-hour model of LPS-induced ALI, the number of intra-alveolar neutrophils obtained by bronchoalveolar lavage was analyzed in wild-type, Icam-1 , and RAGE mice treated with 100 U/kg PC 30 min after intratracheal LPS instillation (Escherichia coli 0111:B4 (10 μg LPS/50 μL PBS)). All values are presented as mean ± SEM from at least three mice per group. Significant differences () to WT control mice are indicated by the asterisks.
