Polymorphisms in the Tumor Necrosis Factor Receptor Genes Affect the Expression Levels of Membrane-Bound Type I and Type II Receptors

Table 3

Genotype and allele distributions of TNFRI and TNFRII gene polymorphisms from healthy individuals from Novosibirsk (South-Western Siberia, Russia, 𝑛=150).

Gene	SNP	Genotype and allele	%	𝑛	𝑃^a
TNFRI	−609 G/T, rs4149570	GG	30.9	46	0.405
		GT	52.3	78
		TT	16.8	25
		G	57
		T	43
TNFRI	−1207 G/C, rs4149569	GG	34.7	52	0.942
		GC	48.7	73
		CC	16.7	25
		G	59
		C	41
TNFRII	−1709 A/T, rs652625	AA	90.7	136	0.548
		AT	9.3	14
		TT	—	—
		A	95
		T	5
TNFRII	−3609 C/T, rs590368	CC	35.3	53	0.45
		CT	50.7	76
		TT	14	21
		C	61
		T	39

aP value for Hardy-Weinberg equilibrium. SNP: single nucleotide polymorphism; TNFR: tumor necrosis factor receptor; GT: Guanidine/Thymine; GC: Guanidine/Cytosine; AT: Adenine/Thymine; CT: Cytosine/Thymine.