The Proinflammatory Cytokine High-Mobility Group Box-1 Mediates Retinal Neuropathy Induced by Diabetes

<table>Gene expression of high-mobility group box-1 (HMGB1) in the retinas was quantified by RT-PCR using a primer given in the Materials and Methods section and was adjusted to the mRNA level of <i>β</i>-actin in each sample. Each measurement was performed at least 3 times. Results are expressed as mean ± SD of at least 6 rats in each group. GA: glycyrrhizic acid; PBS: phosphate buffer saline <svg height="13.95" id="M17" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared with nondiabetic controlled rats. <svg height="13.95" id="M18" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 73.300003 13.95" width="73.300003" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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<g transform="matrix(.017,-0,0,-.017,14.65,13.688)"><path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
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</svg> compared with PBS. <svg height="15.775" id="M19" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 67.387497 15.775" width="67.387497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared with diabetic rats.</table>

Mediators of Inflammation

fig3

Figure 3

Figure 3: The Proinflammatory Cytokine High-Mobility Group Box-1 Mediates Retinal Neuropathy Induced by Diabetes 