Impact of STAT/SOCS mRNA Expression Levels after Major Injury
Figure 1
Posttraumatic IL-10 mRNA expression profile after major trauma in all patients (a), depending on injury severity (NISS, (b)) and depending on outcome (survival > 90 days, (c)), * SNK-test. IL-10 mRNA expression after blunt multiple trauma increased significantly in the early posttraumatic period (6 h–72 h) compared to IL-10 mRNA expression immediately after trauma on admission (A). Patients with a NISS less than 41 points expressed significantly higher IL-10 mRNA levels on admission (A), 24 h, 48 h, and 72 h after trauma, compared to patients with a NISS between 41 and 75 points. Patients who survived the traumatic event showed a significant increase of IL-10 mRNA expression on each time point (6 h–72 h) compared to the IL-10 level detected on admission (A).
