|
| Ref. number | Herb | Outcomes and results | Suggested mechanisms |
|
| [14] | Bambusae caulis | TEWL↓
serum IgE↓ eosinophil↓
spleen IFN-γ↑ TNF-α↓ IL-4↓ IL-13↓ | Suppression of Th2 response and promotion of Th1 response |
|
| [15] | Broussonetia kazinoki | Plasma IgE↓ IL-4↓
skin mast cell↓ | Suppression of Th2 response |
|
| [28] | Alnus japonica | Clinical score↓
serum IgE↓ eosinophil↓
skin IL-4↓ IL-5↓ IL-13↓ iNOS↓ COX-2↓ | Suppression of Th2 response |
|
| [29] | Korean red ginseng | Scratching↓
serum IgE↓ IL-4↓ IL-10↓ | Suppression of Th2 response |
|
| [16] | Cordyceps bassiana | Clinical score↓ epidermal thickness↓
serum IgE↓ histamine↓ skin IFN-γ↓ IL-4↓ mast cell↓ | Suppression of both Th1 and Th2 responses |
|
| [30] | Chelidonium majus | Clinical score↓ ear thickness↓ scratching↓
serum IgE↓ IL-4↓ TNF-α↓ | Suppression of Th2 response |
|
| [31] | Cinnamomum cassia | Serum IgE↓ histamine↓ TNF-α↓
skin IL-4↓ TNF-α↓ TARC↓ | Suppression of Th2 response |
|
| [24] | Terminalia chebula Retzius | Ear thickness↓
skin inflammatory cells↓ eosinophils↓
ear IL-31↓ T-bet positive cell↑ MMP-9↓ | Suppression of Th2 response and promotion of Th1 response |
|
| [9] | Lindera obtusiloba | Ear thickness↓
serum IgE↓ DfE specific IgE↓ histamine↓
ear mast cell↓ IL-4↓ IL-13↓ IL-31↓ TNF-α↓ | Suppression of Th2 response |
|
| [22] | Rehmannia glutinosa | Clinical score↓ ear thickness↓
serum IgE↑ histamine↓
ear IL-4↓ TNF-α↓ TARC↓ MDC↓ RANTES↓ ICAM-1↓ VCAM-1↓ | Suppression of Th2 response |
|
| [17] | Angelicae Dahuricae Radix | Clinical score↓
plasma IgE↓ histamine↓ | Suppression of Th2 response |
|
| [18] | Vernonia amygdalina | Clinical score↓ ear thickness↓ scratching
serum IgE↓ IL-4↓ IL-5↓ MCP-1↓ eotaxin↓ | Suppression of Th2 response |
|
| [25] | Chrysanthemum boreale Makino | Clinical score↓ ear thickness↓ scratching↓
serum IgE↓ TNF-α↓ IL-4↓ | Suppression of Th2 response |
|
| [32] | Mycelium of Phellinus linteus | Clinical score↓ ear thickness↓
serum IgE↓ DfE specific IgE↓ total IgG—
ear IL-12↓ IFN-γ↓ IL-4↓ IL-5↓ IL-10↓ IL-13↓ TNF-α↓ CCL4↓ CCL22↓ CCL17— CCL20— eotaxin— IL-2↓ | Suppression of both Th1 and Th2 responses |
|
| [33] | Psidium guajava | Clinical score↓
serum IgE↓ TARC↓ IL-10↑
ear IFN-γ↓ TNF-α↓ IL-4↓ IL-5↓ IL-13↓ | Suppression of both Th1 and Th2 responses and upregulation of IL-10 |
|
| [34] | Drynaria fortunei | Clinical score↓ ear thickness↓
serum IgE↓ IgG1↓ IgG2a— IL-4↓ IL-6↓ TNF-α↓
ear IFN-γ— IL-4↓ TNF-α↓ IL-6↓ ICAM-1— VCAM-1 | Suppression of Th2 response |
|
| [35] | Schisandra chinensis | Clinical score↓ scratching↓
serum IgE↓ IgM↓ histamine↓
skin histamine receptors↓ spleen IL-4↓ IL-5↓ FcεRIβ↓ | Suppression of Th2 response |
|
| [10] | Illicium verum | Clinical score↓ ear thickness↓
serum IgE↓ histamine↓ IL-6↓ ICAM-1↓
ear IFN-γ↑ IL-4↓ IL-6↓ TNF-α↓ TARC↓ RANTES↓ ICAM-1↓ VCAM-1↓ | Suppression of Th2 response and promotion of Th1 response |
|
| [36] | Chrysanthemum indicum L. | Clinical score↓ ear thickness↓
serum IgE↓ IgG1↓ IFN-γ↓ IL-4↓
skin eosinophil↓ mast cell↓ IFN-γ↓ IL-4↓ IL-13↓
IL-4 : IFN-γ ratio↓ | Suppression of both Th1 and Th2 responses and balancing of Th1/Th2 cell responses |
|
| [37] | Catalpa ovata | Clinical score↓
serum IgE↓
skin mast cell↓ IL-4↓ IL-5↓ IL-6↓ IL-13↓ IL-1b↓ TNF-α↓ | Suppression of Th2 response |
|
| [38] | Astragalus membranaceus | Epidermal thickness↓ dermal thickness↓
serum IgE↓ IL-4↓ IL-5↓ IL-6↓ IL-13↓ TNF-α↓
skin NF-κB↓ | Suppression of Th2 response |
|
| [11] | Pleurotus eryngii | Clinical score↓ ear thickness↓
serum IgE↓ TARC↓
skin mast cell↓ ear IFN-γ↓ TNF-α↓ IL-4↓ IL-5↓ IL-13↓ | Suppression of both Th1 and Th2 responses |
|
