Potent Anti-Inflammatory Activity of Pyrenocine A Isolated from the Marine-Derived Fungus Penicillium paxilli Ma(G)K
Figure 4
Anti-inflammatory effects of pyrenocine A on PGE2 production by macrophages. (a) Pretreatment procedure: cells were pretreated with different concentrations of pyrenocine A (3.75–0.94 μM) for 2 h and then stimulated with LPS (1 μg/mL) during 18 h. (b) Posttreatment procedure: cells were stimulated with LPS (1 μg/mL) for 2 h and then pyrenocine A (3.75–0.94 μM) was added during 18 h. The supernatants were collected, and the production of PGE2 was evaluated. The procedures were performed in triplicate.
