Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2014, Article ID 781519, 13 pages
http://dx.doi.org/10.1155/2014/781519
Research Article

Decreased Inflammatory Responses of Human Lung Epithelial Cells after Ethanol Exposure Are Mimicked by Ethyl Pyruvate

1Department of Trauma, Hand and Reconstructive Surgery, University Hospital Frankfurt, Goethe University, 60590 Frankfurt, Germany
2Department of General Surgery, University Hospital Frankfurt, Goethe University, 60590 Frankfurt, Germany
3Department of Thoracic and Cardiovascular Surgery, University Hospital Frankfurt, Goethe University, 60590 Frankfurt, Germany
4Department of Urology and Pediatric Urology, University Hospital Frankfurt, Goethe University, 60590 Frankfurt, Germany

Received 1 April 2014; Accepted 27 August 2014; Published 3 November 2014

Academic Editor: Jan G. C. van Amsterdam

Copyright © 2014 B. Relja et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Li, P. M. Keyl, G. S. Smith, and S. P. Baker, “Alcohol and injury severity: reappraisal of the continuing controversy,” Journal of Trauma: Injury, Infection and Critical Care, vol. 42, no. 3, pp. 562–569, 1997. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Rehm, R. Room, K. Graham, M. Monteiro, G. Gmel, and C. T. Sempos, “The relationship of average volume of alcohol consumption and patterns of drinking to burden of disease: an overview,” Addiction, vol. 98, no. 9, pp. 1209–1228, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. G. J. Bagby, P. Zhang, D. A. Stoltz, and S. Nelson, “Suppression of the granulocyte colony-stimulating factor response to Escherichia coli challenge by alcohol intoxication,” Alcoholism: Clinical and Experimental Research, vol. 22, no. 8, pp. 1740–1745, 1998. View at Publisher · View at Google Scholar · View at Scopus
  4. D. M. Boé, S. Nelson, P. Zhang, and G. J. Bagby, “Acute ethanol intoxication suppresses lung chemokine production following infection with Streptococcus pneumoniae,” Journal of Infectious Diseases, vol. 184, no. 9, pp. 1134–1142, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. D. M. Boé, S. Nelson, P. Zhang, L. Quinton, and G. J. Bagby, “Alcohol-induced suppression of lung chemokine production and the host defense response to Streptococcus pneumoniae,” Alcoholism: Clinical and Experimental Research, vol. 27, no. 11, pp. 1838–1845, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. D. E. Faunce, M. S. Gregory, and E. J. Kovacs, “Effects of acute ethanol exposure on cellular immune responses in a murine model of thermal injury,” Journal of Leukocyte Biology, vol. 62, no. 6, pp. 733–740, 1997. View at Google Scholar · View at Scopus
  7. K. A. N. Messingham, D. E. Faunce, and E. J. Kovacs, “Alcohol, injury, and cellular immunity,” Alcohol, vol. 28, no. 3, pp. 137–149, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Ruiz, S. Ewig, A. Torres et al., “Severe community-acquired pneumonia: risk factors and follow-up epidemiology,” The American Journal of Respiratory and Critical Care Medicine, vol. 160, no. 3, pp. 923–929, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. P. Zhang, G. J. Bagby, D. M. Boé et al., “Acute alcohol intoxication suppresses the CXC chemokine response during endotoxemia,” Alcoholism: Clinical and Experimental Research, vol. 26, no. 1, pp. 65–73, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. M. D. Bird, M. A. Choudhry, P. E. Molina, and E. J. Kovacs, “Alcohol and trauma: a summary of the Satellite Symposium at the 30th Annual Meeting of the Shock Society,” Alcohol, vol. 43, no. 3, pp. 247–252, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Nau, S. Wutzler, H. Dörr et al., “Liver cirrhosis but not alcohol abuse is associated with impaired outcome in trauma patients−a retrospective, multicentre study,” Injury, vol. 44, no. 5, pp. 661–666, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. R. T. Cook, “Alcohol abuse, alcoholism, and damage to the immune system—a review,” Alcoholism: Clinical and Experimental Research, vol. 22, no. 9, pp. 1927–1942, 1998. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Szabo, P. Mandrekar, L. Girouard, and D. Catalane, “Regulation of human monocyte functions by acute ethanol treatment: decreased tumor necrosis factorα, interleukin-1β and elevated interleukin- 10, and transforming growth factor-β production,” Alcoholism: Clinical and Experimental Research, vol. 20, no. 5, pp. 900–907, 1996. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Mandrekar, D. Catalano, B. White, and G. Szabo, “Moderate alcohol intake in humans attenuates monocyte inflammatory responses: inhibition of nuclear regulatory factor kappa B and induction of interleukin 10,” Alcoholism: Clinical and Experimental Research, vol. 30, no. 1, pp. 135–139, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. A. S. Johansson, K. Johansson-Haque, S. Okret, and J. Palmblad, “Ethyl pyruvate modulates acute inflammatory reactions in human endothelial cells in relation to the NF-κB pathway,” British Journal of Pharmacology, vol. 154, no. 6, pp. 1318–1326, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Berger, U. A. Ajani, C. S. Kase et al., “Light-to-moderate alcohol consumption and the risk of stroke among U.S. Male physicians,” The New England Journal of Medicine, vol. 341, no. 21, pp. 1557–1564, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Lustenberger, K. Inaba, G. Barmparas et al., “Ethanol intoxication is associated with a lower incidence of admission coagulopathy in severe traumatic brain injury patients,” Journal of Neurotrauma, vol. 28, no. 9, pp. 1699–1706, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. H. D. Sesso, “Alcohol and cardiovascular health: recent findings,” American Journal of Cardiovascular Drugs, vol. 1, no. 3, pp. 167–172, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. M. P. Fink, “Ethyl pyruvate,” Current Opinion in Anaesthesiology, vol. 21, no. 2, pp. 160–167, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. K. K. Kao and M. P. Fink, “The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds,” Biochemical Pharmacology, vol. 80, no. 2, pp. 151–159, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Wang, P. Yin, S. Huang, J. Wang, and R. Sun, “Ethyl pyruvate protects against lipopolysaccharide-induced white matter injury in the developing rat brain,” International Journal of Developmental Neuroscience, vol. 31, no. 3, pp. 181–188, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. C. C. Jacobs, S. J. Holcombe, V. L. Cook, J. C. Gandy, J. G. Hauptman, and L. M. Sordillo, “Ethyl pyruvate diminishes the inflammatory response to lipopolysaccharide infusion in horses,” Equine Veterinary Journal, vol. 45, no. 3, pp. 333–339, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. L. F. Li, K. C. Kao, C. T. Yang, C. C. Huang, and Y. Y. Liu, “Ethyl pyruvate reduces ventilation-induced neutrophil infiltration and oxidative stress,” Experimental Biology and Medicine, vol. 237, no. 6, pp. 720–727, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. Z.-G. Luan, H. Zhang, X.-C. Ma, C. Zhang, and R.-X. Guo, “Therapeutic treatment with ethyl pyruvate attenuates the severity of liver injury in rats with severe acute pancreatitis,” Pancreas, vol. 41, no. 5, pp. 729–737, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Ulloa, M. Ochani, H. Yang et al., “Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 19, pp. 12351–12356, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Holzer, F. Schübel, P. Konietzny, K. Wilhelm, W.-O. Bechstein, and D. Henrich, “Interleukin 8 mRNA gene expression in peripheral and intra-abdominal neutrophils during human secondary peritonitis,” Shock, vol. 23, no. 6, pp. 501–506, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. A.-S. M. Jonsson and J. E. W. Palmblad, “Effects of ethanol on NF-κB activation, production of myeloid growth factors, and adhesive events in human endothelial cells,” The Journal of Infectious Diseases, vol. 184, no. 6, pp. 761–769, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. R. Maiya, K. J. Buck, R. Adron Harris, and R. Dayne Mayfield, “Ethanol-sensitive sites on the human dopamine transporter,” Journal of Biological Chemistry, vol. 277, no. 34, pp. 30724–30729, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Famili, D. A. Ammar, and M. Y. Kahook, “Ethyl pyruvate treatment mitigates oxidative stress damage in cultured trabecular meshwork cells,” Molecular Vision, vol. 19, pp. 1304–1309, 2013. View at Google Scholar · View at Scopus
  30. A. S. Johansson and J. Palmblad, “Ethyl pyruvate modulates adhesive and secretory reactions in human lung epithelial cells,” Life Sciences, vol. 84, no. 23-24, pp. 805–809, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. H. Ajisaka, M. Okajima, Y. Goto, T. Taniguchi, and H. Inaba, “Effects of acute low-dose ethanol on inflammatory reactions to endotoxin-induced shock in rats,” Journal of Toxicological Sciences, vol. 37, no. 3, pp. 649–654, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. B. Relja, C. Höhn, F. Bormann et al., “Acute alcohol intoxication reduces mortality, inflammatory responses and hepatic injury after haemorrhage and resuscitation in vivo,” British Journal of Pharmacology, vol. 165, pp. 1188–1199, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. B. Relja, D. Henrich, G. Wetzel et al., “Effects of acute ethanol gavage on intestinal integrity after hemorrhage/resuscitation,” Scandinavian Journal of Gastroenterology, vol. 48, no. 4, pp. 448–458, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. H. C. Do-Umehara, C. Chen, D. Urich et al., “Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ,” Nature Immunology, vol. 14, no. 5, pp. 461–469, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. T. Zhu, D.-X. Wang, W. Zhang et al., “Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-κB,” PLoS ONE, vol. 8, no. 2, Article ID e56407, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. L. C. Monção-Ribeiro, V. R. Cagido, G. Lima-Murad et al., “Lipopolysaccharide-induced lung injury: role of P2X7 receptor,” Respiratory Physiology and Neurobiology, vol. 179, no. 2-3, pp. 314–325, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. T. C. Allen and A. Kurdowska, “Interleukin 8 and acute lung injury,” Archives of Pathology and Laboratory Medicine, vol. 138, no. 2, pp. 266–269, 2014. View at Publisher · View at Google Scholar · View at Scopus
  38. J. Karavitis, E. L. Murdoch, C. R. Gomez, L. Ramirez, and E. J. Kovacs, “Acute ethanol exposure attenuates pattern recognition receptor activated macrophage functions,” Journal of Interferon and Cytokine Research, vol. 28, no. 7, pp. 413–422, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Bhatty, B. L. Jan, W. Tan, S. B. Pruett, and B. Nanduri, “Role of acute ethanol exposure and TLR4 in early events of sepsis in a mouse model,” Alcohol, vol. 45, no. 8, pp. 795–803, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. R. Bals and P. S. Hiemstra, “Innate immunity in the lung: how epithelial cells fight against respiratory pathogens,” European Respiratory Journal, vol. 23, no. 2, pp. 327–333, 2004. View at Publisher · View at Google Scholar · View at Scopus
  41. L. K. Fogli, M. S. Sundrud, S. Goel et al., “T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia,” Journal of Immunology, vol. 191, no. 6, pp. 3100–3111, 2013. View at Publisher · View at Google Scholar · View at Scopus
  42. F. Maradonna and O. Carnevali, “Vitellogenin, zona radiate protein, cathepsin D and heat shock protein 70 as biomakers of exposure to xenobiotics,” Biomarkers, vol. 12, no. 3, pp. 240–255, 2007. View at Publisher · View at Google Scholar · View at Scopus
  43. S. C. Park, J. I.-Y. Lim, Y. T. Jeen et al., “Ethanol-induced DNA damage and repair-related molecules in human intestinal epithelial Caco-2 cells,” Molecular Medicine Reports, vol. 5, no. 4, pp. 1027–1032, 2012. View at Publisher · View at Google Scholar · View at Scopus
  44. F. Bardag-Gorce, “Effects of ethanol on the proteasome interacting proteins,” World Journal of Gastroenterology, vol. 16, no. 11, pp. 1349–1357, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. M. A. Collins, E. J. Neafsey, K. Wang, N. J. Achille, R. M. Mitchell, and S. Sivaswamy, “Moderate ethanol preconditioning of rat brain cultures engenders neuroprotection against dementia-inducing neuroinflammatory proteins: possible signaling mechanisms,” Molecular Neurobiology, vol. 41, no. 2-3, pp. 420–425, 2010. View at Publisher · View at Google Scholar · View at Scopus