Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2014, Article ID 781649, 11 pages
http://dx.doi.org/10.1155/2014/781649
Research Article

Th9/IL-9 Profile in Human Echinococcosis: Their Involvement in Immune Response during Infection by Echinococcus granulosus

1Hematologic Disease Center and Xinjiang Uygur Autonomous Region Research Institute of Hematology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China
2Department of Clinical Laboratory, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China
3State Key Laboratory Incubation Base of Major Diseases in Xinjiang and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China
4Basic Medical College of Xinjiang Medical University, Urumqi, Xinjiang 830011, China

Received 17 December 2013; Revised 21 February 2014; Accepted 21 February 2014; Published 30 March 2014

Academic Editor: Yves Denizot

Copyright © 2014 Nannan Pang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Piarroux, R. Piarroux, R. Giorgi et al., “Clinical features and evolution of alveolar echinococcosis in France from 1982 to 2007: results of a survey in 387 patients,” Journal of Hepatology, vol. 55, no. 5, pp. 1025–1033, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Eckert and P. Deplazes, “Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern,” Clinical Microbiology Reviews, vol. 17, no. 1, pp. 107–135, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. H. R. Rahimi, B. Sarkari, T. Mohammadzadeh, and S. M. Sadjjadi, “Immune responses to antigens of in vitro reared Echinococcus granulosus adult worms in Balb/c mice,” Iranian Journal of Immunology, vol. 8, no. 4, pp. 236–243, 2011. View at Google Scholar · View at Scopus
  4. S. Bresson-Hadni, J.-P. Miguet, G. Mantion, P. Giraudoux, and D.-A. Vuitton, “Alveolar echinococcosis: a disease comparable to a slow growing cancer,” Bulletin de l'Academie Nationale de Medecine, vol. 192, no. 6, pp. 1131–1139, 2008. View at Google Scholar · View at Scopus
  5. R. Riganò, B. Buttari, E. De Falco et al., “Echinococcus granulosus-specific T-cell lines derived from patients at various clinical stages of cystic echinococcosis,” Parasite Immunology, vol. 26, no. 1, pp. 45–52, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Daneshvar, R. Burchmore, P. Hagan, and R. S. Phillips, “Leishmania major H-line attenuated under pressure of gentamicin, induces a Th1 response which protects susceptible BALB/c mice against infection with virulent L. major,” Parasitology, vol. 136, no. 11, pp. 1243–1250, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. M. T. Rogan, “T-cell activity associated with secondary infections and implanted cysts of Echinococcus granulosus in BALB/c mice,” Parasite Immunology, vol. 20, no. 11, pp. 527–533, 1998. View at Google Scholar · View at Scopus
  8. V. Dardalhon, A. Awasthi, H. Kwon et al., “IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3- effector T cells,” Nature Immunology, vol. 9, no. 12, pp. 1347–1355, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Veldhoen, C. Uyttenhove, J. van Snick et al., “Transforming growth factor-β “reprograms” the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset,” Nature Immunology, vol. 9, no. 12, pp. 1341–1346, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. R. M. Talaat, N. M. Ali, and H. S. Elwakil, “Impact of Schistosoma mansoni and Echinococcus granulosus experimental coinfection on interleukin 10 and interferon gamma cytokines profile,” Experimental Parasitology, vol. 134, no. 4, pp. 474–481, 2013. View at Google Scholar
  11. L. E. Harrington, R. D. Hatton, P. R. Mangan et al., “Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages,” Nature Immunology, vol. 6, no. 11, pp. 1123–1132, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Sauer, E. Rochet, I. Lahmar et al., “The local immune response to intraocular Toxoplasma re-challenge: less pathology and better parasite control through Treg/Th1/Th2 induction,” International Journal For Parasitology, vol. 43, no. 9, pp. 721–728, 2013. View at Publisher · View at Google Scholar
  13. B. Jayaprakasam, N. Yang, M. C. Wen et al., “Constituents of the anti-asthma herbal formula ASHMI(TM) synergistically inhibit IL-4 and IL-5 secretion by murineTh2 memory cells, and eotaxin by human lung fibroblasts in vitro,” Journal of Integrative Medicine, vol. 11, no. 3, pp. 195–205, 2013. View at Google Scholar
  14. S. Saglani, S. Lui, N. Ullmann et al., “IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma,” Journal of Allergy and Clinical Immunology, vol. 132, no. 3, pp. 676.e13–685.e13, 2013. View at Google Scholar
  15. M. T. Wong, J. J. Ye, M. N. Alonso et al., “Regulation of human Th9 differentiation by type i interferons and IL-21,” Immunology and Cell Biology, vol. 88, no. 6, pp. 624–631, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. H.-C. Chang, S. Sehra, R. Goswami et al., “The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation,” Nature Immunology, vol. 11, no. 6, pp. 527–534, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Bettelli, M. Oukka, and V. K. Kuchroo, “TH-17 cells in the circle of immunity and autoimmunity,” Nature Immunology, vol. 8, no. 4, pp. 345–350, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Ryba-Stanislawowska, M. Skrzypkowska, J. Mysliwska, and M. Mysliwiec, “The serum IL-6 profile and treg/th17 peripheral cell populations in patients with type 1 diabetes,” Mediators of Inflammation, vol. 2013, Article ID 205284, 7 pages, 2013. View at Publisher · View at Google Scholar
  19. T. Tuxun, J. H. Wang, R. Y. Lin et al., “Th17/ Treg imbalance in patients with liver cystic echinococcosis,” Parasite Immunology, vol. 34, no. 11, pp. 520–527, 2012. View at Google Scholar
  20. WHO Informal Working Group, “Interna-tional classification of ultrasound images in cystic echinococcosis for application in clinical and field epidemiological settings,” Acta Tropica, vol. 85, no. 2, pp. 253–261, 2003. View at Google Scholar
  21. M. T. Rogan, W. Y. Hai, R. Richardson, E. Zeyhle, and P. S. Craig, “Hydatid cysts: does every picture tell a story?” Trends in Parasitology, vol. 22, no. 9, pp. 431–438, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Beriou, E. M. Bradshaw, E. Lozano et al., “TGF-β induces IL-9 production from human Th17 cells,” Journal of Immunology, vol. 185, no. 1, pp. 46–54, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Eller, D. Wolf, J. M. Huber et al., “IL-9 production by regulatory T cells recruits mast cells that are essential for regulatory T cell-induced immune suppression,” Journal of Immunology, vol. 186, no. 1, pp. 83–91, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. G. L. Stephens, B. Swerdlow, E. Benjamin et al., “IL-9 is a Th17-derived cytokine that limits pathogenic activity in organ-specific autoimmune disease,” European Journal of Immunology, vol. 41, no. 4, pp. 952–962, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Anuradha, P. J. George, L. E. Hanna et al., “IL-4-, TGF-β-, and IL-1-dependent expansion of parasite antigen-specific Th9 cells is associated with clinical pathology in human lymphatic filariasis,” Journal of Immunology, vol. 191, no. 5, pp. 2466–2473, 2013. View at Google Scholar
  26. R. Riganò, E. Profumo, B. Buttari, A. Teggi, and A. Siracusano, “Cytokine gene expression in peripheral blood mononuclear cells (PBMC) from patients with pharmacologically treated cystic echinococcosis,” Clinical and Experimental Immunology, vol. 118, no. 1, pp. 95–101, 1999. View at Publisher · View at Google Scholar · View at Scopus
  27. E. E. Kara, I. Comerford, C. R. Bastow et al., “Distinct chemokine receptor axes regulate Th9 cell trafficking to allergic and autoimmune inflammatory sites,” The Journal of Immunology, vol. 191, no. 3, pp. 1110–1117, 2013. View at Google Scholar
  28. J. Wang, M. Pae, S. N. Meydani, and D. Wu, “Green tea epigallocatechin-3-gallate modulates differentiation of naïve CD4+ T cells into specific lineage effector cells,” Journal of Molecular Medicine, vol. 91, no. 4, pp. 485–495, 2013. View at Google Scholar
  29. H. Horka, V. Staudt, M. Klein et al., “The tick salivary protein sialostatin L inhibits the Th9-derived production of the asthma-promoting cytokine IL-9 and is effective in the prevention of experimental asthma,” Journal of Immunology, vol. 188, no. 6, pp. 2669–2676, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. W. Elyaman, R. Bassil, E. M. Bradshaw et al., “Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells,” Immunity, vol. 36, no. 4, pp. 623–634, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Wang, C. Zhang, X. Wei et al., “TGF-beta and TGF-beta/Smad signaling in the interactions between Echinococcus multilocularis and its hosts,” PLoS ONE, vol. 8, no. 2, Article ID e55379, 2013. View at Google Scholar
  32. D. A. Vuitton and B. Gottstein, “Echinococcus multilocularis and its intermediate host: a model of parasite-host interplay,” Journal of Biomedicine and Biotechnology, vol. 2010, Article ID 923193, 14 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Chandrasekhar and S. C. Parija, “Serum antibody & Th2 cytokine profiles in patients with cystic echinococcosis,” Indian Journal of Medical Research, vol. 130, no. 6, pp. 731–735, 2009. View at Google Scholar · View at Scopus
  34. D. Mezioug and C. Touil-Boukoffa, “Cytokine profile in human hydatidosis: possible role in the immunosurveillance of patients infected with Echinococcus granulosus,” Parasite, vol. 16, no. 1, pp. 57–64, 2009. View at Google Scholar · View at Scopus
  35. R. Jabeen and M. H. Kaplan, “The symphony of the ninth: the development and function of Th9 cells,” Current Opinion in Immunology, vol. 24, no. 3, pp. 303–307, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. G. Cheng, M. Arima, K. Honda et al., “Anti-interleukin-9 antibody treatment inhibits airway inflammation and hyperreactivity in mouse asthma model,” The American Journal of Respiratory and Critical Care Medicine, vol. 166, no. 3, pp. 409–416, 2002. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Amri, D. Mezioug, and C. Touil-Boukoffa, “Involvement of IL-10 and IL-4 in evasion strategies of Echinococcus granulosus to host immune response,” European Cytokine Network, vol. 20, no. 2, pp. 63–68, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. S. Stäger, T. Joshi, and R. Bankoti, “Immune evasive mechanisms contributing to persistent Leishmania donovani infection,” Immunologic Research, vol. 47, no. 1–3, pp. 14–24, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. C.-L. Tang, J.-H. Lei, T. Wang et al., “Effect of CD4+CD25+ regulatory T cells on the immune evasion of Schistosoma japonicum,” Parasitology Research, vol. 108, no. 2, pp. 477–480, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. C. Touil-Boukoffa, B. Bauvois, J. Sancéau, B. Hamrioui, and J. Wietzerbin, “Production of nitric oxide (NO) in human hydatidosis: relationship between nitrite production and interferon-γ levels,” Biochimie, vol. 80, no. 8-9, pp. 739–744, 1998. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Amri, S. A. Aissa, H. Belguendouz, D. Mezioug, and C. Touil-Boukoffa, “In vitro antihydatic action of IFN-γ is dependent on the nitric oxide pathway,” Journal of Interferon and Cytokine Research, vol. 27, no. 9, pp. 781–787, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. A. L. Pritchard, M. L. Carroll, J. G. Burel, O. J. White, S. Phipps, and J. W. Upham, “Innate IFNs and plasmacytoid dendritic cells constrain Th2 cytokine responses to rhinovirus: a regulatory mechanism with relevance to asthma,” The Journal of Immunology, vol. 188, no. 12, pp. 5898–5905, 2012. View at Google Scholar
  43. M. C. Siracusa, E. D. Wojno, and D. Artis, “Functional heterogeneity in the basophil cell lineage,” Advances in Immunology, vol. 115, pp. 141–159, 2012. View at Google Scholar