Adenosine A_2A Receptors Modulate Acute Injury and Neuroinflammation in Brain Ischemia

Table 1

Adenosine A_2A receptor ligands used in brain ischemia “in vivo” and “in vitro” models.

	Brain ischemia model	References
Adenosine A2A receptor agonists
CGS21680	Global ischemia in rat	[44]
	Global ischemia in gerbil	[45]
	Focal ischemia in rat	[46]
	OGD hippocampal slices	[47, 48]
APEC	Global ischemia in gerbil	[49]
Adenosine A2A receptor antagonists
CGS15943	Global ischemia in gerbil	[50]
	Global ischemia in rat	[51]
CSC	Global ischemia in gerbil	[49, 52]
	Focal ischemia in hypertensive rat	[53]
CP66713	Global ischemia in gerbil	[52]
ZM241385	Global ischemia in rat	[54]
	OGD hippocampal slices	[55, 56]
SCH58261	Hypoxia/ischemia in neonatal rat	[57]
	Focal ischemia in rat	[58–62]
	Global ischemia in newborn piglet	[63]
	OGD hippocampal slices	[55, 64]
	OGD cerebrocortical slices	[65, 66]
DMPX	OGD hippocampal slices	[48]

APEC: 2-[(2-aminoethylamino)-carbonylethylphenylethylamino]-5′-N-ethylcarboxoamidoadenosine; CGS15943: 9-chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine; CGS21680: 2-p-(2-Carboxyethyl)phenethylamino-5′-N-ethylcarboxamidoadenosine; CP66713: 4-amino[1,2,4]triazolo[4,3a]quinoxalines; CSC: 8-(3-chlorostyryl)caffeine; DMPX: 3,7-dimethyl-1-propargylxanthine; OGD: oxygen and glucose deprivation; SCH58261: 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-[1,2,4]triazolo[1,5-c]pyrimidine; ZM241385: 4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-yl-amino]ethyl)phenol.