Peptidases from Latex of Carica candamarcensis Upregulate COX-2 and IL-1 mRNA Transcripts against Salmonella enterica ser. Typhimurium-Mediated Inflammation
Figure 2
Histologic pattern of the liver and spleen of mice pretreated with P1G10 72 hours after infection by Salmonella Typhimurium. (a) Liver of mice in the PBS group, showing severe vacuolation, necrosis of individual hepatocytes with diffuse distribution (thin arrow), and thrombosis (star); (b) liver of mice in the experimental group (P1G10, 10 mg/Kg), demonstrating hepatic necrosis (thin arrow) and accumulation of mononuclear cells (large arrow); (c) spleens of mice in the control group, showing lymphoid depletion (thin arrow) and the presence of giant cells (large arrow); (d) spleens of mice in the experimental group with preserved appearance of the white pulp and red pulp.
