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Mediators of Inflammation
Volume 2014, Article ID 820304, 12 pages
http://dx.doi.org/10.1155/2014/820304
Research Article

Development and Validation of Protein Microarray Technology for Simultaneous Inflammatory Mediator Detection in Human Sera

1School of Life Sciences, The University of Nottingham, A Floor West Block, Queen’s Medical Centre, Nottingham NG7 2UH, UK
2Roche Products Limited, 6 Falcon Way, Shire Park, Welwyn Garden City AL7 1TW, UK
3Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt
4Nottingham Respiratory Research, University of Nottingham Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, UK

Received 20 May 2014; Revised 8 September 2014; Accepted 8 September 2014; Published 14 October 2014

Academic Editor: Vera L. Petricevich

Copyright © 2014 Senthooran Selvarajah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. J. Lesko and A. J. Atkinson Jr., “Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: criteria, validation, strategies,” Annual Review of Pharmacology and Toxicology, vol. 41, pp. 347–366, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Nowsheen, K. Aziz, M. I. Panayiotidis, and A. G. Georgakilas, “Molecular markers for cancer prognosis and treatment: have we struck gold?” Cancer Letters, vol. 327, no. 1-2, pp. 142–152, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Wang, N. Diao, C. Lu et al., “Evaluation of the diagnostic potential of IP-10 and IL-2 as biomarkers for the diagnosis of active and latent tuberculosis in a BCG-vaccinated population,” PLoS ONE, vol. 7, no. 12, Article ID e51338, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. M. G. Madariaga, Z. Jalali, and S. Swindells, “Clinical utility of interferon gamma assay in the diagnosis of tuberculosis,” Journal of the American Board of Family Medicine, vol. 20, no. 6, pp. 540–547, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. A. W. Ansari, N. Bhatnagar, O. Dittrich-Breiholz, M. Kracht, R. E. Schmidt, and H. Heiken, “Host chemokine (C-C motif) ligand-2 (CCL2) is differentially regulated in HIV type 1 (HIV-1)-infected individuals,” International Immunology, vol. 18, no. 10, pp. 1443–1451, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Deswal, N. J. Petersen, A. M. Feldman, J. B. Young, B. G. White, and D. L. Mann, “Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the Vesnarinone Trial (VEST),” Circulation, vol. 103, no. 16, pp. 2055–2059, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Orús, E. Roig, F. Perez-Villa et al., “Prognostic value of serum cytokines in patients with congestive heart failure,” The Journal of Heart and Lung Transplantation, vol. 19, no. 5, pp. 419–425, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Lanquillon, J.-C. Krieg, U. Bening-Abu-Shach, and H. Vedder, “Cytokine production and treatment response in major depressive disorder,” Neuropsychopharmacology, vol. 22, no. 4, pp. 370–379, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. S. M. O'Brien, P. Scully, P. Fitzgerald, L. V. Scott, and T. G. Dinan, “Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy,” Journal of Psychiatric Research, vol. 41, no. 3-4, pp. 326–331, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. F. Zhou, M. M. Wang, L. Yuan, Z. P. Cheng, Z. Q. Wu, and H. Chen, “Sensitive sandwich ELISA based on a gold nanoparticle layer for cancer detection,” Analyst, vol. 137, no. 8, pp. 1779–1784, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Gonzalez-Gonzalez, R. Jara-Acevedo, S. Matarraz et al., “Nanotechniques in proteomics: protein microarrays and novel detection platforms,” European Journal of Pharmaceutical Sciences, vol. 45, no. 4, pp. 499–506, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. L. A. Tessler and R. D. Mitra, “Sensitive single-molecule protein quantification and protein complex detection in a microarray format,” Proteomics, vol. 11, no. 24, pp. 4731–4735, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Wingren, A. Sandström, R. Segersvärd et al., “Identification of serum biomarker signatures associated with pancreatic cancer,” Cancer Research, vol. 72, no. 10, pp. 2481–2490, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Tighe, O. Negm, I. Todd, and L. Fairclough, “Utility, reliability and reproducibility of immunoassay multiplex kits,” Methods, vol. 61, no. 1, pp. 23–29, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. K. V. Desai, C. J. Kavanaugh, A. Calvo, and J. E. Green, “Chipping away at breast cancer: insights from microarray studies of human and mouse mammary cancer,” Endocrine-Related Cancer, vol. 9, no. 4, pp. 207–220, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Selvarajah, The development and application of an antibody microarray as a diagnostic platform for COPD [Ph.D. thesis], University of Nottingham, 2013, http://etheses.nottingham.ac.uk/3572/.
  17. D. A. Armbruster and T. Pry, “Limit of blank, limit of detection and limit of quantitation,” The Clinical Biochemist Reviews, vol. 29, supplement 1, pp. S49–S52, 2008. View at Google Scholar
  18. Guidance for Industry: Bioanalytical Method Validation, US Food and Drug Administration, 2001, http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm070107.pdf.
  19. D. A. Fici, W. McCormick, D. W. Brown, J. E. Herrmann, V. Kumar, and Z. L. Awdeh, “A protein multiplex microarray substrate with high sensitivity and specificity,” Journal of Immunological Methods, vol. 363, no. 1, pp. 60–66, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. B. A. Wood, R. M. Troyer, J. A. TerWee, and S. VandeWoude, “Microsphere immunoassay for the detection of cytokines in domestic cat (Felis catus) plasma: elevated IL-12/23 in acute feline immunodeficiency virus infections,” Veterinary Immunology and Immunopathology, vol. 145, no. 3-4, pp. 604–610, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. H. Dietrich, K. Hu, M. Ruffin et al., “Safety, tolerability, and pharmacokinetics of a single dose of pasireotide long-acting release in healthy volunteers: a single-center Phase I study,” European Journal of Endocrinology, vol. 166, no. 5, pp. 821–828, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Anderson, J. David, S. Pearlman, and J. Schmidt, “Evaluation of multiplex immunoassay results,” Genetic Engineering and Biotechnology News, vol. 31, no. 8, pp. 24–25, 2011. View at Google Scholar · View at Scopus
  23. M. J. Binnicker, D. J. Jespersen, and J. A. Harring, “Evaluation of three multiplex flow immunoassays compared to an enzyme immunoassay for the detection and differentiation of IgG class antibodies to herpes simplex virus types 1 and 2,” Clinical and Vaccine Immunology, vol. 17, no. 2, pp. 253–257, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Urbanowska, S. Mangialaio, C. Zickler et al., “Protein microarray platform for the multiplex analysis of biomarkers in human sera,” Journal of Immunological Methods, vol. 316, no. 1-2, pp. 1–7, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. B. Schweitzer and S. F. Kingsmore, “Measuring proteins on microarrays,” Current Opinion in Biotechnology, vol. 13, no. 1, pp. 14–19, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. P. R. Knight, A. Sreekumar, J. Siddiqui et al., “Development of a sensitive microarray immunoassay and comparison with standard enzyme-linked immunoassay for cytokine analysis,” Shock, vol. 21, no. 1, pp. 26–30, 2004. View at Google Scholar · View at Scopus
  27. S. X. Leng, J. E. McElhaney, J. D. Walston, D. Xie, N. S. Fedarko, and G. A. Kuchel, “ELISA and multiplex technologies for cytokine measurement in inflammation and aging research,” Journals of Gerontology—Series A Biological Sciences and Medical Sciences, vol. 63, no. 8, pp. 879–884, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. M. F. Elshal and J. P. McCoy, “Multiplex bead array assays: performance evaluation and comparison of sensitivity to ELISA,” Methods, vol. 38, no. 4, pp. 317–323, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. J.-G. Walter, F. Stahl, M. Reck et al., “Protein microarrays: reduced autofluorescence and improved LOD,” Engineering in Life Sciences, vol. 10, no. 2, pp. 103–108, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. M.-A. Valentin, S. Ma, A. Zhao, F. Legay, and A. Avrameas, “Validation of immunoassay for protein biomarkers: bioanalytical study plan implementation to support pre-clinical and clinical studies,” Journal of Pharmaceutical and Biomedical Analysis, vol. 55, no. 5, pp. 869–877, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. A. A. Ellington, I. J. Kullo, K. R. Bailey, and G. G. Klee, “Measurement and quality control issues in multiplex protein assays: a case study,” Clinical Chemistry, vol. 55, no. 6, pp. 1092–1099, 2009. View at Publisher · View at Google Scholar · View at Scopus