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Mediators of Inflammation
Volume 2014, Article ID 826987, 9 pages
http://dx.doi.org/10.1155/2014/826987
Research Article

Splenic Stromal Cells from Aged Mice Produce Higher Levels of IL-6 Compared to Young Mice

1Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
2Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

Received 20 November 2013; Revised 14 January 2014; Accepted 15 January 2014; Published 4 March 2014

Academic Editor: Huiyun Zhang

Copyright © 2014 Jihyun Park et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Mammucari and R. Rizzuto, “Signaling pathways in mitochondrial dysfunction and aging,” Mechanisms of Ageing and Development, vol. 131, no. 7-8, pp. 536–543, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. A. L. Gruver, L. L. Hudson, and G. D. Sempowski, “Immunosenescence of ageing,” Journal of Pathology, vol. 211, no. 2, pp. 144–156, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. M. E. Starr, B. M. Evers, and H. Saito, “Age-associated increase in cytokine production during systemic inflammation: adipose tissue as a major source of IL-6,” Journals of Gerontology A, vol. 64, no. 7, pp. 723–730, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Maggio, J. M. Guralnik, D. L. Longo, and L. Ferrucci, “Interleukin-6 in aging and chronic disease: a magnificent pathway,” Journals of Gerontology, vol. 61, no. 6, pp. 575–584, 2006. View at Google Scholar · View at Scopus
  5. D. Sarkar and P. B. Fisher, “Molecular mechanisms of aging-associated inflammation,” Cancer Letters, vol. 236, no. 1, pp. 13–23, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Franceschi, M. Bonafè, S. Valensin et al., “Inflamm-aging. An evolutionary perspective on immunosenescence,” Annals of the New York Academy of Sciences, vol. 908, pp. 244–254, 2000. View at Google Scholar · View at Scopus
  7. E. J. Kovacs, C. R. Gomez, J. Karavitis et al., “Interleukin-6 contributes to age-related alteration of cytokine production by macrophages,” Mediators of Inflammation, vol. 2010, Article ID 475139, 7 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Pawelec, “Human immunosenescence: is it infectious?” Immunological Reviews, vol. 205, pp. 257–268, 2005. View at Google Scholar
  9. E. J. Kovacs, J. L. Palmer, C. F. Fortin, T. Fülöp Jr., D. R. Goldstein, and P.-J. Linton, “Aging and innate immunity in the mouse: impact of intrinsic and extrinsic factors,” Trends in Immunology, vol. 30, no. 7, pp. 319–324, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. P. J. Busse and S. K. Mathur, “Age-related changes in immune function: effect on airway inflammation,” Journal of Allergy and Clinical Immunology, vol. 126, no. 4, pp. 690–699, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. V. Cardona, M. Guilarte, O. Luengo, M. Labrador-Horrillo, A. Sala-Cunil, and T. Garriga, “Allergic diseases in the elderly,” Clinical and Translational Allergy, vol. 1, article 11, 2011. View at Google Scholar
  12. S. Omoigui, “The Interleukin-6 inflammation pathway from cholesterol to aging—role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases,” Immunity and Ageing, vol. 4, article 1, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. W. E. Naugler and M. Karin, “The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer,” Trends in Molecular Medicine, vol. 14, no. 3, pp. 109–119, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Huang, D. D. Patel, and K. G. Manton, “The immune system in aging: roles of cytokines, T cells and NK cells,” Frontiers in Bioscience, vol. 10, pp. 192–215, 2005. View at Google Scholar · View at Scopus
  15. A. Salminen, J. Huuskonen, J. Ojala, A. Kauppinen, K. Kaarniranta, and T. Suuronen, “Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging,” Ageing Research Reviews, vol. 7, no. 2, pp. 83–105, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. W. B. Ershler and E. T. Keller, “Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty,” Annual Review of Medicine, vol. 51, pp. 245–270, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. J. K. Kiecolt-Glaser, K. J. Preacher, R. C. MacCallum, C. Atkinson, W. B. Malarkey, and R. Glaser, “Chronic stress and age-related increases in the proinflammatory cytokine IL-6,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 15, pp. 9090–9095, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. K. E. Wellen and G. S. Hotamisligil, “Inflammation, stress, and diabetes,” Journal of Clinical Investigation, vol. 115, no. 5, pp. 1111–1119, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Ogura, M. Murakami, Y. Okuyama et al., “Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction,” Immunity, vol. 29, no. 4, pp. 628–636, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. J. G. Cyster, “Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs,” Annual Review of Immunology, vol. 23, pp. 127–159, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Roozendaal and R. E. Mebius, “Stromal cell-immune cell interactions,” Annual Review of Immunology, vol. 29, pp. 23–43, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Link, T. K. Vogt, S. Favre et al., “Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells,” Nature Immunology, vol. 8, no. 11, pp. 1255–1265, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. J. M. den Haan, R. E. Mebius, and G. Kraal, “Stromal cells of the mouse spleen,” Frontiers in Immunology, vol. 3, pp. 1–5, 2012. View at Google Scholar
  24. E. D. Boehmer, J. Goral, D. E. Faunce, and E. J. Kovacs, “Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression,” Journal of Leukocyte Biology, vol. 75, no. 2, pp. 342–349, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Shortman and S. H. Naik, “Steady-state and inflammatory dendritic-cell development,” Nature Reviews Immunology, vol. 7, no. 1, pp. 19–30, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Saito, C. Patterson, Z. Hu et al., “Expression and self-regulatory function of cardiac interleukin-6 during endotoxemia,” American Journal of Physiology: Heart and Circulatory Physiology, vol. 279, no. 5, pp. H2241–H2248, 2000. View at Google Scholar · View at Scopus
  27. J. J. O'Shea, A. Ma, and P. Lipsky, “Cytokines and autoimmunity,” Nature Reviews Immunology, vol. 2, no. 1, pp. 37–45, 2002. View at Google Scholar · View at Scopus
  28. S. Q. Latifi, M. A. O'Riordan, A. D. Levine, and A. Stallion, “Persistent elevation of serum interleukin-6 in intraabdominal sepsis identifies those with prolonged length of stay,” Journal of Pediatric Surgery, vol. 39, no. 10, pp. 1548–1552, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. K. Ishihara and T. Hirano, “IL-6 in autoimmune disease and chronic inflammatory proliferative disease,” Cytokine and Growth Factor Reviews, vol. 13, no. 4-5, pp. 357–368, 2002. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Murakami, Y. Okuyama, H. Ogura et al., “Local microbleeding facilitates IL-6-and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells,” Journal of Experimental Medicine, vol. 208, no. 1, pp. 103–114, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. N. Komatsu and H. Takayanagi, “Inflammation and bone destruction in arthritis: synergistic activity of immune and mesenchymal cells in joints,” Frontiers in Immunology, vol. 3, pp. 1–11, 2012. View at Google Scholar
  32. N. Kumagai, Y. Chiba, M. Hosono et al., “Involvement of pro-inflammatory cytokines and microglia in an age-associated neurodegeneration model, the SAMP10 mouse,” Brain Research, vol. 1185, no. 1, pp. 75–85, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. B. M. Meador, C. P. Krzyszton, R. W. Johnson, and K. A. Huey, “Effects of IL-10 and age on IL-6, IL-1β, and TNF-α responses in mouse skeletal and cardiac muscle to an acute inflammatory insult,” Journal of Applied Physiology, vol. 104, no. 4, pp. 991–997, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. C. R. Gomez, J. Goral, L. Ramirez, M. Kopf, and E. J. Kovacs, “Aberrant acute-phase response in aged interleukin-6 knockout mice,” Shock, vol. 25, no. 6, pp. 581–585, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Gajanant, “Bacterial infections and the pathogenesis of autoimmune conditions,” British Journal of Medical Practitioners, vol. 2, pp. 6–13, 2009. View at Google Scholar
  36. K. Tanaka and T. Kishimoto, “Targeting interleukin-6: all the way to treat autoimmune and inflammatory diseases,” International Journal of Biological Sciences, vol. 8, pp. 1227–1236, 2012. View at Google Scholar
  37. J. Wolf, B. Weinberger, C. R. Arnold, A. B. Maier, R. G. Westendorp, and B. Grubeck-Loebenstein, “The effect of chronological age on the inflammatory response of human fibroblasts,” Experimental Gerontology, vol. 47, pp. 749–753, 2012. View at Google Scholar
  38. Y. Katz, O. Nadiv, and Y. Beer, “Interleukin-17 enhances tumor necrosis factor alpha-induced synthesis of interleukins 1, 6, and 8 in skin and synovial fibroblasts: a possible role as a “fine-tuning cytokine” in inflammation processes,” Arthritis Rheumatism, vol. 44, pp. 2176–2184, 2001. View at Google Scholar
  39. J. Hartupee, C. Liu, M. Novotny, X. Li, and T. Hamilton, “IL-17 enhances chemokine gene expression through mRNA stabilization,” Journal of Immunology, vol. 179, no. 6, pp. 4135–4141, 2007. View at Google Scholar · View at Scopus