Chitosan Oligosaccharides Attenuate Ocular Inflammation in Rats with Experimental Autoimmune Anterior Uveitis
Effects of COS on histological changes in the iris/ciliary bodies (ICB) and leukocyte infiltration in the aqueous humor (AqH). (a) A representative H&E-stained ICB from normal or PBS-treated or high- or low-dose COS groups at day 14. The EAAU rats showed increased leukocyte infiltration in the ICB and the AqH, and the inflammation was attenuated by treatment with low-dose or high-dose COS. Original magnification 100x. (b) The quantification of leukocytes in the AqH at days 10, 14, 17, and 20. The EAAU rats treated with low-dose or high-dose COS showed significantly reduced leukocyte numbers in the AqH. The data are expressed as the mean ± SD (∗ compared with the PBS-treated group; # compared with the normal group; & compared with the low-dose group by Kruskal-Wallis test with post hoc Dunn test; for each group).