IVS1 −397T>C Estrogen Receptor α Polymorphism Is Associated with Low-Grade Systemic Inflammatory Response in Type 1 Diabetic Girls

Table 1

Clinical characteristics of girls with type 1 diabetes differing in the IVS1 −397T>C estrogen receptor α polymorphism.

Clinical parameter	CC	CT	TT	𝑃	𝑃^∗	𝑃^∗∗	𝑃^∗∗∗
𝑁	37	70	45
Age (years)	14.2 ± 3.4	14.0 ± 3.6	13.2 ± 3.8	0.81	0.86	0.79	0.74
Duration of diabetes (years)	5.3 ± 3.3	4.1 ± 3.1	4.6 ± 3.8	0.53	0.09	0.58	0.36
BMI (kg/m^2)	20.1 ± 3.5	19.4 ± 3.6	18.7 ± 3.8	0.05	0.28	0.39	0.01
HbA1c (%)	8.9 ± 2.5	8.6 ± 2.1	9.2 ± 2.4	0.21	0.28	0.17	0.67
CRP (mg/mL)	1.6 ± 1.4	1.8 ± 1.6	2.5 ± 2.3	0.1	0.5	0.06	0.02
Albumin excretion rate (mg/24 h)	19.8 ± 16.2	20.8 ± 19.4	23.3 ± 22.6	0.6	0.39	0.08	0.37
Serum creatinine level (mg/dL)	0.75 ± 0.13	0.74 ± 0.17	0.73 ± 0.16	0.98	0.33	0.34	0.61

Differences were calculated by the Kruskal-Wallis ANOVA test. Data are presented as mean ± SD.
𝑃: the comparison between three analyzed genotypes CC, CT, and TT.
𝑃^∗: post hoc comparison between patients bearing CC and CT genotypes.
𝑃^∗∗: post hoc comparison between patients bearing CT and TT genotypes.
𝑃^∗∗∗: post hoc comparison between patients bearing CC and TT genotypes.