IVS1 −397T>C Estrogen Receptor α Polymorphism Is Associated with Low-Grade Systemic Inflammatory Response in Type 1 Diabetic Girls

Table 5

The level of serum cytokines in analyzed subjects.

	DM1 girls with coexisting microvascular complications (𝑛=41)	DM1 girls free from microvascular complications (𝑛=111)	Control group (𝑛=84)	𝑃	𝑃^∗	𝑃^∗∗	𝑃^∗∗∗
IL-6 (pg/mL)	0.9 (0.4/1.8)	0.8 (0.2/1.5)	0.4 (0.2/0.6)	0.0004	0.34	0.001	<0.0001
TNF-α (pg/mL)	1.8 (1.1/2.8)	0.0 (0/0.8)	0.0 (0/0)	<0.0001	<0.0001	0.007	<0.0001
VEGF (pg/mL)	216.8 (57.4/439.3)	98.4 (43.6/181.1)	113.4 (29.6/289.7)	0.03	0.008	0.17	0.05
IL-10 (pg/mL)	0.5 (0/1.4)	0.6 (0.1/1.8)	0 (0/1.5)	0.44	0.14	0.001	0.64

Data are presented as median and 10./90. percentile. Differences were calculated by the Kruskal-Wallis ANOVA test and post hoc NIR test.
𝑃: comparison between three analyzed subject groups.
𝑃^∗: post hoc comparison between DM1 girls with complications and DM1 group without complications.
𝑃^∗∗: post hoc comparison between DM1 girls without complications and the control group.
𝑃^∗∗∗: post hoc comparison between DM1 girls with complications and the control group.