Tumor Necrosis Factor Induces Developmental Stage-Dependent Structural Changes in the Immature Small Intestine
Figure 4
TNFR1 is required for TNF-induced ileal villus blunting and villus area loss. Small intestinal villus length, area, and epithelial cell counts were measured as above in mice lacking one or both TNFRs (R1−/−, R2−/−, or R1-2−/−). Mice treated with TNF were measured and compared to controls of the same strain. Data are shown as the difference from controls, which are set to 100%. Significant differences () from controls in TNF treatment are denoted by an asterisk.
