Predictive Criteria to Study the Pathogenesis of Malaria-Associated ALI/ARDS in Mice
Figure 2
Radiography of the lungs, hypoxemia, and body temperature over time. (a) From left to right, X-rays from NI and infected DBA/2 mice that died with ALI/ARDS and HP showing different lung opacification scores on the 7th DAI. (b) Lung opacification scores on the 7th DAI. Mice that will later die with ALI/ARDS have a higher lung opacification score compared with mice that will die with HP (; , Mann-Whitney test of scores taken from two separate experiments). NI mice do not have any lung opacification and are assigned score zero. (c) PaO2/FiO2 values in P. berghei ANKA-infected mice on the 7th DAI. Results from three grouped experiments ( mice, ; Mann-Whitney test). (d) Body temperatures in DBA/2 mice infected with P. berghei ANKA slightly increased on the 5th DAI from 37.1°C in the NI mice to 37.3 in the ALI/ARDS mice and 37.4°C in the HP mice). However, the temperatures dropped and the mice became hypothermic (especially the ALI/ARDS mice), with mean temperatures of 33.0°C on the 7th DAI and 32.8°C on the 9th DAI. Results are from three grouped experiments ( mice; , two-way ANOVA with Bonferroni post test). Data (d) represents means and SEM. The dashed line represents the mean value of NI mice. NI: noninfected mice; ALI/ARDS: acute lung injury/acute respiratory distress syndrome; HP: hyperparasitemia.
