Protective Effect of Cytosolic Phospholipase A2 Inhibition against Inflammation and Degeneration by Promoting Regulatory T Cells in Rats with Experimental Autoimmune Encephalomyelitis

Figure 2

Treatment with the cPLA₂ inhibitor AX059 reduced brain and spinal cord damage in EAE induced in Lewis rats. The figures shows hematoxylin and eosin (H&E)-stained sections from AX059-treated ((a) brain; (b) spinal cord) and vehicle-treated ((e) brain; (f) spinal cord) rats; spinal cord sections from AX059-treated (c) or vehicle-treated (g) rats stained with Luxol fast blue; and Foxp3 expression in spinal cord sections from AX059-treated (d) or vehicle-treated (h) rats by immunohistochemical staining.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)