The Acute Phase of Trypanosoma cruzi Infection Is Attenuated in 5-Lipoxygenase-Deficient Mice

Figure 7

Splenic T-cell properties, effector/memory T cells, and regulatory T cells in control, infected WT and infected 5-LO^−/− mice (𝑛=8/group): (a) proliferation; (b) cytokine production profile after anti-CD3 stimulation; and (c) Th1/Th2 cytokine recall response to soluble T. cruzi antigen. ^∗𝑃<0.001 versus uninfected group; ^#𝑃<0.001 versus infected WT mice. (d) CD4⁺CD45RB^low and CD8⁺CD45RB^low; (e) CD4⁺CD44^highCD62L^low and CD8⁺CD44^highCD62L^low; and (f) CD4⁺CD25⁺GITR⁺. Stimulation index (SI) was generated by the ratio between the OD (570 nm) obtained in noninfected/infected cells. Data are from one of two independent experiments. Student’s 𝑡-test (^#𝑃<0.01 versus infected WT mice).

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