The Acute Phase of Trypanosoma cruzi Infection Is Attenuated in 5-Lipoxygenase-Deficient Mice
Figure 8
Levels of vasoactive/vasomotor mediators and relevance of cys-LTs in mice acutely infected with T. cruzi (/group): (a) total serum nitrite (nitrite/nitrate) levels and (b) LTC4 production by peritoneal cells upon stimulation with calcium ionophore. Data are from one of three independent experiments. versus infected WT mice. (c) Protein extravasation in the peritoneal cavity (colorimetric assay of extravascular dye leakage). Dotted line indicates the mean Evans blue D.O. found in control mice. Data are from one experiment representative of three separate experiments. versus infected WT mice. (d) Effect of cys-LT receptor antagonist on survival in T. cruzi-infected mice: (black squares) vehicle-treated infected WT mice and (gray squares) infected WT mice treated with montelukast (10 mg/kg) from postinoculation day 14 to postinoculation day 34 and monitored for 26 days. Data are from one experiment representative of two separate experiments. Wilcoxon signed-rank test versus vehicle-treated infected WT mice.
